Gene

tp53

ID
ZDB-GENE-990415-270
Name
tumor protein p53
Symbol
tp53 Nomenclature History
Previous Names
  • p53 (1)
  • brp53
  • drp53
  • etID22686.5 (1)
  • fb40d06
  • wu:fb40d06 (1)
  • zgc:111919
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including cell fate commitment involved in formation of primary germ layer; intracellular signal transduction; and regulation of macromolecule metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; hematopoietic system; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
250 figures from 204 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
55 figures from 40 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
fb105Allele with one delinsUnknownUnknownTALEN
hg91Allele with one deletionExon 5FrameshiftCRISPR
hg116Allele with one insertionExon 7FrameshiftCRISPR
hg117Allele with one insertionExon 4FrameshiftCRISPR
hsi6Allele with multiple variantsUnknownUnknownCRISPR
hsi7Allele with multiple variantsUnknownUnknownCRISPR
hu888Allele with one point mutationAcceptor Splice Site of Intron 8Splice SiteENU
ihb135Allele with one delinsUnknownUnknownCRISPR
ihb136Allele with one deletionUnknownUnknownCRISPR
is55Allele with one delinsIntron 1UnknownTALEN
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Sequence Targeting Reagents
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Human Disease
Associated With tp53 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adrenocortical carcinoma Alliance {Adrenocortical carcinoma, pediatric} 202300
breast cancer Alliance Breast cancer, somatic 114480
choroid plexus papilloma Alliance {Choroid plexus papilloma} 260500
colorectal cancer Alliance {Colorectal cancer} 114500
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
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Associated With tp53 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010991 p53, tetramerisation domain
Domain IPR011615 p53, DNA-binding domain
Family IPR002117 p53 tumour suppressor family
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length p53, DNA-binding domain p53-like tetramerisation domain superfamily p53-like transcription factor, DNA-binding domain superfamily p53/RUNT-type transcription factor, DNA-binding domain superfamily p53, tetramerisation domain p53 tumour suppressor family
UniProtKB:A0A8M2BCD8 InterPro 370
UniProtKB:A0A8M2BCE6 InterPro 257
UniProtKB:B0R0M3 InterPro 369
UniProtKB:P79734 InterPro PDB 373
UniProtKB:A0A0B4VFS7 InterPro 261
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tp53-201 (1) Ensembl 2,211 nt
mRNA tp53-203 (1) Ensembl 2,204 nt
mRNA tp53-206 (1) Ensembl 2,208 nt
mRNA tp53-207 (1) Ensembl 1,195 nt
mRNA tp53-208 (1) Ensembl 1,956 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tp53 monoclonal Mouse
  • IHC
  • WB
4
Ab10-tp53 monoclonal Mouse
  • IHC
  • WB
9
Ab11-tp53 monoclonal IgG Mouse
  • IHC
  • WB
Abcam plc
18
Ab2-tp53 monoclonal IgG1 Mouse
  • IHC
  • WB
3
Ab6-tp53 monoclonal Mouse
  • WB
2
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Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(hsp70l:tp53,cryaa:Cerulean)
  • Danio rerio
1Jin et al., 2022
Tg(tp53-002:GFP)
  • Danio rerio
1 (6)
Tg(tp53:EGFP)
  • tp53
  • Danio rerio
Zebrafish Nomenclature Committee
Tg(tp53:Venus,Xla.Cryg:mCherry)
  • tp53
  • Danio rerio
  • Xenopus laevis
1Badrock et al., 2020
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-114C12ZFIN Curated Data
EncodesESTfb40d06ZFIN Curated Data
EncodescDNAMGC:111919ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTP5317
Conserved genome location (synteny) (2)
Amino acid sequence comparison (6)
Other (1)
MouseTrp5311
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
1 - 10 of 1,642
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