Gene
tp53
- ID
- ZDB-GENE-990415-270
- Name
- tumor protein p53
- Symbol
- tp53 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including cell fate commitment involved in formation of primary germ layer; intracellular signal transduction; and regulation of macromolecule metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; hematopoietic system; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 250 figures from 204 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111919 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 55 figures from 40 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
fb105 | Allele with one delins | Unknown | Unknown | TALEN | |
hg91 | Allele with one deletion | Exon 5 | Frameshift | CRISPR | |
hg116 | Allele with one insertion | Exon 7 | Frameshift | CRISPR | |
hg117 | Allele with one insertion | Exon 4 | Frameshift | CRISPR | |
hsi6 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
hsi7 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
hu888 | Allele with one point mutation | Acceptor Splice Site of Intron 8 | Splice Site | ENU | |
ihb135 | Allele with one delins | Unknown | Unknown | CRISPR | |
ihb136 | Allele with one deletion | Unknown | Unknown | CRISPR | |
is55 | Allele with one delins | Intron 1 | Unknown | TALEN |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-tp53 | (8) | |
CRISPR2-tp53 | Thomas et al., 2014 | |
CRISPR3-tp53 | Thomas et al., 2014 | |
CRISPR4-tp53 | Thomas et al., 2014 | |
CRISPR5-tp53 | (2) | |
CRISPR6-tp53 | Prykhozhij et al., 2018 | |
CRISPR7-tp53 | (5) | |
CRISPR8-tp53 | (6) | |
CRISPR9-tp53 | (2) | |
CRISPR10-tp53 | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
adrenocortical carcinoma | Alliance | {Adrenocortical carcinoma, pediatric} | 202300 |
breast cancer | Alliance | Breast cancer, somatic | 114480 |
choroid plexus papilloma | Alliance | {Choroid plexus papilloma} | 260500 |
colorectal cancer | Alliance | {Colorectal cancer} | 114500 |
hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR010991 | p53, tetramerisation domain |
Domain | IPR011615 | p53, DNA-binding domain |
Family | IPR002117 | p53 tumour suppressor family |
Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | p53, DNA-binding domain | p53-like tetramerisation domain superfamily | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | p53, tetramerisation domain | p53 tumour suppressor family |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BCD8 | InterPro | 370 | ||||||
UniProtKB:A0A8M2BCE6 | InterPro | 257 | ||||||
UniProtKB:B0R0M3 | InterPro | 369 | ||||||
UniProtKB:P79734 | InterPro PDB | 373 | ||||||
UniProtKB:A0A0B4VFS7 | InterPro | 261 |
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Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:tp53,cryaa:Cerulean) |
|
| 1 | Jin et al., 2022 | |
Tg(tp53-002:GFP) |
|
| 1 | (6) | |
Tg(tp53:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
Tg(tp53:Venus,Xla.Cryg:mCherry) |
|
| 1 | Badrock et al., 2020 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-114C12 | ZFIN Curated Data | |
Encodes | EST | fb40d06 | ZFIN Curated Data | |
Encodes | cDNA | MGC:111919 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001271820 (1) | 2236 nt | ||
Genomic | GenBank:AL928875 (1) | 158038 nt | ||
Polypeptide | UniProtKB:G1K2L5 (1) | 374 aa |
- Ahmad, A., Bogoch, Y., Shvaizer, G., Guler, N., Levy, K., Elkouby, Y.M. (2025) The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of germ granules. PLoS Genetics. 21:e1010868e1010868
- Gang, K., Chen, Q., Sun, J., Zhang, T., Cai, P., Ni, R., Ma, J. (2025) Khdrbs1 drives redifferentiation of bipotential progenitor cell by inhibiting p53 in zebrafish biliary-mediated liver regeneration. Development (Cambridge, England). :
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Ma, J., Chen, Y., Song, J., Ruan, Q., Li, L., Luo, L. (2025) Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug. Proceedings of the National Academy of Sciences of the United States of America. 122:e2413719122e2413719122
- Madesh, S., Murugan, R., Sau, A., Jubie, S., Swaroop, A.K., Rajagopal, R., Kumaradoss, K.M., Arockiaraj, J. (2025) Nano-Encapsulated Coumarin Derivative, CS-QM2 Inhibits Neoplasm Growth: Experimented in Zebrafish Model. Journal of biochemical and molecular toxicology. 39:e70239e70239
- Ramakrishnan, G., Miskolci, V., Hunter, M., Giese, M.A., Münch, D., Hou, Y., Eliceiri, K.W., Lasarev, M.R., White, R.M., Huttenlocher, A. (2025) Real-time imaging reveals a role for macrophage protrusive motility in melanoma invasion. The Journal of cell biology. 224(2):
- Sertori, R., Truong, B., Singh, M.K., Shinton, S., Price, R., Sharo, A., Shultes, P., Sunderam, U., Rana, S., Srinivasan, R., Datta, S., Font-Burgada, J., Brenner, S.E., Puck, J.M., Wiest, D.L. (2025) Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia. Frontiers in immunology. 16:15398481539848
- Wang, C., Zhong, Y., Zhang, Y., Jiang, Y., Wang, C., An, L., Luo, C., Yang, L., He, Z., Yang, Y., Luo, M., Mao, M., Wang, W., Liu, Q., Shi, Y., Ping, Y.F. (2025) Cd248a regulates pericyte development and viability in zebrafish. Communications biology. 8:451451
- Wang, X., Liu, M., Zhang, Y., Ma, D., Wang, L., Liu, F. (2025) Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 122:e2420534122e2420534122
- Wang, Y., Xu, G., Li, H., Gao, J., Du, X., Jiang, W., Ji, G., Liu, Z. (2025) Zglp-1 is a novel essential transcriptional regulator for sex reversal in zebrafish. Marine life science & technology. 7:256270256-270
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