Gene
vsx1
- ID
- ZDB-GENE-990415-205
- Name
- visual system homeobox 1 homolog, chx10-like
- Symbol
- vsx1 Nomenclature History
- Previous Names
-
- etID309864.17 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables chromatin binding activity and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including negative regulation of axial mesodermal cell fate specification; nervous system development; and paraxial mesodermal cell fate specification. Predicted to be active in nucleus. Is expressed in blastomere; immature eye; nervous system; and neural tube. Human ortholog(s) of this gene implicated in corneal dystrophy; keratoconus; and posterior polymorphous corneal dystrophy 1. Orthologous to human VSX1 (visual system homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73233 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vsx1 | Zhang et al., 2020 | |
| CRISPR2-vsx1 | Letelier et al., 2023 | |
| CRISPR3-vsx1 | Letelier et al., 2023 | |
| MO1-vsx1 | N/A | (4) |
| MO2-vsx1 | N/A | (2) |
| MO4-vsx1 | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| keratoconus | Alliance | Keratoconus 1 | 148300 |
| ?Craniofacial anomalies and anterior segment dysgenesis syndrome | 614195 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CVC domain | Homedomain-like superfamily | Homeobox, conserved site | Homeobox domain-containing protein | Homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QBH3 | InterPro | 340 | |||||
| UniProtKB:O42250 | InterPro | 344 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(vsx1:GFP) |
|
| 1 | (40) | |
| Tg(vsx1:Cerulean) |
|
| 1 | (3) | |
| Tg(vsx1:GAL4,myl7:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67N1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73233 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131333 (1) | 1587 nt | ||
| Genomic | GenBank:AL929290 (2) | 168517 nt | ||
| Polypeptide | UniProtKB:O42250 (1) | 344 aa |
- Emmerich, K., Walker, S.L., Wang, G., White, D.T., Ceisel, A., Wang, F., Teng, Y., Chunawala, Z., Graziano, G., Nimmagadda, S., Saxena, M.T., Qian, J., Mumm, J.S. (2023) Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses. PLoS Genetics. 19:e1010905e1010905
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Hickey, G.J., Wike, C.L., Nie, X., Guo, Y., Tan, M., Murphy, P.J., Cairns, B.R. (2022) Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos. eLIFE. 11:
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Guo, R., Ge, K., Wang, Y., Lu, M., Li, F., Tian, L., Gan, L., Sheng, D. (2021) LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish. Scientific Reports. 11:1977
- Itoh, T., Inoue, S., Sun, X., Kusuda, R., Hibi, M., Shimizu, T. (2021) Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(11):1618-1633
- Lahne, M., Brecker, M., Jones, S.E., Hyde, D.R. (2021) The Regenerating Adult Zebrafish Retina Recapitulates Developmental Fate Specification Programs. Frontiers in cell and developmental biology. 8:617923
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
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