Gene
mstnb
- ID
- ZDB-GENE-990415-165
- Name
- myostatin b
- Symbol
- mstnb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables growth factor activity. Involved in negative regulation of growth; negative regulation of striated muscle tissue development; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within with a negative effect on cardiac muscle myoblast proliferation. Acts upstream of or within several processes, including negative regulation of cardiac muscle myoblast proliferation; negative regulation of growth rate; and striated muscle tissue development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; heart; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns5 | Allele with one deletion | Unknown | Unknown | TALEN | |
| cig3 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| ihb167 | Allele with one delins | Unknown | Unknown | TALEN | |
| ou2052 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| sa41499 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sou4 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| zf1027 | Allele with one delins | Exon 1 | Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mstnb | (2) | |
| CRISPR2-mstnb | Zebrafish Nomenclature Committee | |
| MO1-mstnb | N/A | (2) |
| TALEN1-mstnb | (2) | |
| TALEN2-mstnb | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myostatin-related muscle hypertrophy | Alliance | ?Muscle hypertrophy | 614160 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|
| UniProtKB:O42222 | InterPro | 374 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.2mstn:GFP) |
|
| 1 | (3) | |
| Tg(myl7:mstnb-2A-Hsa.HISTH2BJ-EGFP) |
| 1 | Dogra et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-3O3 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-72B14 | ZFIN Curated Data | |
| Encodes | EST | eu171 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:109749 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131019 (1) | 2178 nt | ||
| Genomic | GenBank:BX323586 (1) | 171172 nt | ||
| Polypeptide | UniProtKB:O42222 (1) | 374 aa |
- Donaka, R., Zheng, H., Ackert-Bicknell, C.L., Karasik, D. (2024) Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. Gene. 936:149123
- Ramli, ., Aramaki, T., Watanabe, M., Kondo, S. (2024) Piezo1 mutant zebrafish as a model of idiopathic scoliosis. Frontiers in genetics. 14:13213791321379
- Cigliola, V., Shoffner, A., Lee, N., Ou, J., Gonzalez, T.J., Hoque, J., Becker, C.J., Han, Y., Shen, G., Faw, T.D., Abd-El-Barr, M.M., Varghese, S., Asokan, A., Poss, K.D. (2023) Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Nature communications. 14:48574857
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705
- Bian, W.P., Pu, S.Y., Xie, S.L., Wang, C., Deng, S., Strauss, P.R., Pei, D.S. (2021) Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell death discovery. 7:250
- Gyimah, E., Xu, H., Dong, X., Qiu, X., Zhang, Z., Bu, Y., Akoto, O. (2021) Developmental neurotoxicity of low concentrations of bisphenol A and S exposure in zebrafish. Chemosphere. 262:128045
- Lanes, C.F.C., Pedron, F.A., Bergamin, G.T., Bitencourt, A.L., Dorneles, B.E.R., Villanova, J.C.V., Dias, K.C., Riolo, K., Oliva, S., Savastano, D., Giannetto, A. (2021) Black Soldier Fly (Hermetia illucens) Larvae and Prepupae Defatted Meals in Diets for Zebrafish (Danio rerio). Animals : an open access journal from MDPI. 11(3):
- Liu, M., Tang, L., Hu, C., Sun, B., Huang, Z., Chen, L. (2021) Interaction between probiotic additive and perfluorobutanesulfonate pollutant on offspring growth and health after parental exposure using zebrafish. Ecotoxicology and environmental safety. 214:112107
- Sundarrajan, L., Rajeswari, J.J., Weber, L.P., Unniappan, S. (2021) The sympathetic/beta-adrenergic pathway mediates irisin regulation of cardiac functions in zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 259:111016
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