Gene
mdm2
- ID
- ZDB-GENE-990415-153
- Name
- MDM2 proto-oncogene
- Symbol
- mdm2 Nomenclature History
- Previous Names
-
- etID309863.4 (1)
- sb:eu923
- zgc:109834
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including blood; digestive system; head; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 87 figures from 69 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109834 (11 images)
- eu923 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| pd314 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa14240 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16808 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20278 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26298 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sq25 | Allele with one deletion | Exon 7 | Premature Stop | zinc finger nuclease | |
| sq26 | Allele with one insertion | Exon 7 | Premature Stop | zinc finger nuclease | |
| sq27 | Allele with one insertion | Exon 7 | Premature Stop | zinc finger nuclease | |
| sq28 | Allele with one deletion | Exon 7 | Inframe Deletion | zinc finger nuclease | |
| uab9 | Allele with one deletion | Exon 7 | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mdm2 | Shoffner et al., 2020 | |
| CRISPR2-mdm2 | Shoffner et al., 2020 | |
| MO1-mdm2 | N/A | (8) |
| MO2-mdm2 | N/A | (3) |
| MO3-mdm2 | N/A | (3) |
| TALEN1-mdm2 | Thomas et al., 2014 | |
| TALEN2-mdm2 | Wang et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase Mdm2 | MDM2, modified RING finger, HC subclass | p53 negative regulator Mdm2/Mdm4 | SWIB/MDM2 domain | SWIB/MDM2 domain superfamily | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:O42354 | InterPro PDB | 445 | |||||||||
| UniProtKB:A0A8M2BC69 | InterPro | 486 | |||||||||
| UniProtKB:Q561Z0 | InterPro | 475 | |||||||||
| UniProtKB:A0A8N1Z1T6 | InterPro | 475 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:LOXP-BFP-LOXP-dnmdm2-2A-mCherry) |
| 1 | Shoffner et al., 2020 | ||
| TgBAC(mdm2:EGFP) |
|
| 1 | Shoffner et al., 2020 | |
| Tg(mdm2:GFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149P5 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-86A5 | ZFIN Curated Data | |
| Encodes | EST | eu923 | Thisse et al., 2005 | |
| Encodes | EST | fc16b11 | ||
| Encodes | cDNA | MGC:109834 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113866 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192439 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001365432 (1) | 2855 nt | ||
| Genomic | GenBank:BX001003 (1) | 212403 nt | ||
| Polypeptide | UniProtKB:A0A8M2BC69 (1) | 486 aa |
- Gang, K., Chen, Q., Sun, J., Zhang, T., Cai, P., Ni, R., Ma, J. (2025) Khdrbs1 drives redifferentiation of bipotential progenitor cell by inhibiting p53 in zebrafish biliary-mediated liver regeneration. Development (Cambridge, England). :
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Wang, C., Zhong, Y., Zhang, Y., Jiang, Y., Wang, C., An, L., Luo, C., Yang, L., He, Z., Yang, Y., Luo, M., Mao, M., Wang, W., Liu, Q., Shi, Y., Ping, Y.F. (2025) Cd248a regulates pericyte development and viability in zebrafish. Communications biology. 8:451451
- Wang, X., Liu, M., Zhang, Y., Ma, D., Wang, L., Liu, F. (2025) Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 122:e2420534122e2420534122
- Xia, X., Song, W., Zhang, F., Fan, Y., Zhang, B., Chen, X. (2025) ctdsp2 Knockout Induces Zebrafish Craniofacial Dysplasia via p53 Signaling Activation. International Journal of Molecular Sciences. 26:
- Xiao, W., Cheng, J., Zhang, L., Li, X., Zhang, J., Ning, G. (2025) Deficiency of psmb6 suppresses proteasome activity and promotes apoptosis in larval zebrafish brain. Biochemical and Biophysical Research Communications. 755:151574151574
- Flentke, G.R., Wilkie, T.E., Baulch, J., Huang, Y., Smith, S.M. (2024) Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PLoS One. 19:e0304557e0304557
- Jones, R.A., Cooper, F., Kelly, G., Barry, D., Renshaw, M.J., Sapkota, G., Smith, J.C. (2024) Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response. Open Biology. 14:240194240194
- Kobar, K., Tuzi, L., Fiene, J.A., Burnley, E., Galpin, K.J.C., Midgen, C., Laverty, B., Subasri, V., Wen, T.T., Hirst, M., Moksa, M., Carles, A., Cao, Q., Shlien, A., Malkin, D., Prykhozhij, S.V., Berman, J.N. (2024) tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes. Biochimica et biophysica acta. Molecular basis of disease. 1871:167612167612
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
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