Gene
hoxc6a
- ID
- ZDB-GENE-990415-113
- Name
- homeobox C6a
- Symbol
- hoxc6a Nomenclature History
- Previous Names
-
- hoxc-6
- hoxc6
- etID228114.23 (1)
- ZF-61
- zgc:101882
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; mesoderm; nervous system; pectoral fin; and somite. Orthologous to human HOXC6 (homeobox C6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140528 (11 images)
- eu620 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Maeno et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hoxc6a | (2) | |
MO1-hoxc6a | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Antennapedia-type homeobox | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|---|
UniProtKB:P15862 | InterPro | 231 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hoxc6a-201
(1)
|
Ensembl | 757 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-81P22 | ZFIN Curated Data | |
Encodes | EST | eu620 | Thisse et al., 2005 | |
Encodes | EST | IMAGE:7140528 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:101882 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192224 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131123 (1) | 696 nt | ||
Genomic | GenBank:BX005254 (1) | 160012 nt | ||
Polypeptide | UniProtKB:P15862 (1) | 231 aa |
- Adachi, U., Koita, R., Seto, A., Maeno, A., Ishizu, A., Oikawa, S., Tani, T., Ishizaka, M., Yamada, K., Satoh, K., Nakazawa, H., Furudate, H., Kawakami, K., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403809121e2403809121
- Maeno, A., Koita, R., Nakazawa, H., Fujii, R., Yamada, K., Oikawa, S., Tani, T., Ishizaka, M., Satoh, K., Ishizu, A., Sugawara, T., Adachi, U., Kikuchi, M., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Hox code responsible for the pattering of the anterior vertebrae in zebrafish. Development (Cambridge, England). 151(14):
- Satoh, K., Maeno, A., Adachi, U., Ishizaka, M., Yamada, K., Koita, R., Nakazawa, H., Oikawa, S., Fujii, R., Furudate, H., Kawamura, A. (2024) Physical constraints on the positions and dimensions of the zebrafish swim bladder by surrounding bones. Journal of anatomy. :
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Wang, J., Fei, F., Berberoglu, M.A., Sun, S., Wang, L., Dong, Z., Wang, X. (2018) Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis. Journal of molecular cell biology. 10(6):586-588
- Barsh, G.R., Isabella, A.J., Moens, C.B. (2017) Vagus Motor Neuron Topographic Map Determined by Parallel Mechanisms of hox5 Expression and Time of Axon Initiation. Current biology : CB. 27(24):3812-3825.e3
- Yu, C., Yao, X., Zhao, L., Wang, P., Zhang, Q., Zhao, C., Yao, S., Wei, Y. (2017) Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation. Neoplasia (New York, N.Y.). 19:606-616
- San, B., Chrispijn, N.D., Wittkopp, N., van Heeringen, S.J., Lagendijk, A.K., Aben, M., Bakkers, J., Ketting, R.F., Kamminga, L.M. (2016) Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Scientific Reports. 6:24658
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