Gene
hoxb5a
- ID
- ZDB-GENE-980526-70
- Name
- homeobox B5a
- Symbol
- hoxb5a Nomenclature History
- Previous Names
-
- hox-2.1
- hox-B5
- hoxb5
- wu:fc38c09
- z-18
- ZF-21
- ZF21
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development and cell fate specification. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mesenchyme; mesoderm; neural tube; and somite. Orthologous to human HOXB5 (homeobox B5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu480 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Maeno et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxb5a | Barsh et al., 2017 | |
| CRISPR2-hoxb5a | Isabella et al., 2020 | |
| CRISPR3-hoxb5a | Maeno et al., 2024 | |
| MO1-hoxb5a | N/A | Waxman et al., 2008 |
| MO2-hoxb5a | N/A | Dalgin et al., 2020 |
| MO3-hoxb5a | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Antennapedia-type homeobox | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:P09014 | InterPro | 275 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxb5a-201
(1)
|
Ensembl | 1,790 nt | ||
| mRNA | ottdart00000001811 (1) | Havana | 1,953 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-72A16 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-254O17 | (2) | |
| Encodes | EST | eu480 | Thisse et al., 2005 | |
| Encodes | EST | fc38c09 | ||
| Encodes | cDNA | MGC:86849 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131101 (1) | 1800 nt | ||
| Genomic | GenBank:AL645782 (1) | 119385 nt | ||
| Polypeptide | UniProtKB:P09014 (1) | 275 aa |
- Maeno, A., Koita, R., Nakazawa, H., Fujii, R., Yamada, K., Oikawa, S., Tani, T., Ishizaka, M., Satoh, K., Ishizu, A., Sugawara, T., Adachi, U., Kikuchi, M., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Hox code responsible for the pattering of the anterior vertebrae in zebrafish. Development (Cambridge, England). 151(14):
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Wang, H., He, J., Han, X., Wu, X., Ye, X., Lv, W., Zu, Y. (2023) hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated Heart Malformation in Bosley-Salih-Alorainy Syndrome. Biology. 12(7):
- Albert, L., Nagpal, J., Steinchen, W., Zhang, L., Werel, L., Djokovic, N., Ruzic, D., Hoffarth, M., Xu, J., Kaspareit, J., Abendroth, F., Royant, A., Bange, G., Nikolic, K., Ryu, S., Dou, Y., Essen, L.O., Vázquez, O. (2022) Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. ACS central science. 8:57-66
- Weiss, J.M., Hunter, M.V., Cruz, N.M., Baggiolini, A., Tagore, M., Ma, Y., Misale, S., Marasco, M., Simon-Vermot, T., Campbell, N.R., Newell, F., Wilmott, J.S., Johansson, P.A., Thompson, J.F., Long, G.V., Pearson, J.V., Mann, G.J., Scolyer, R.A., Waddell, N., Montal, E.D., Huang, T.H., Jonsson, P., Donoghue, M.T.A., Harris, C.C., Taylor, B.S., Xu, T., Chaligné, R., Shliaha, P.V., Hendrickson, R., Jungbluth, A.A., Lezcano, C., Koche, R., Studer, L., Ariyan, C.E., Solit, D.B., Wolchok, J.D., Merghoub, T., Rosen, N., Hayward, N.K., White, R.M. (2022) Anatomic position determines oncogenic specificity in melanoma. Nature. 604(7905):354-361
- Howard, A.G., Baker, P.A., Ibarra-García-Padilla, R., Moore, J.A., Rivas, L.J., Tallman, J.J., Singleton, E.W., Westheimer, J.L., Corteguera, J.A., Uribe, R.A. (2021) An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution. eLIFE. 10:
- Pillay, S., Takahashi, H., Carninci, P., Kanhere, A. (2021) Antisense RNAs during early vertebrate development are divided in groups with distinct features. Genome research. 31(6):995-1010
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Dalgin, G., Prince, V.E. (2020) Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Developmental Biology. 471:1-9
- Isabella, A.J., Barsh, G.R., Stonick, J.A., Dubrulle, J., Moens, C.B. (2020) Retinoic Acid Organizes the Zebrafish Vagus Motor Topographic Map via Spatiotemporal Coordination of Hgf/Met Signaling. Developmental Cell. 53(3):344-357.e5
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