Gene
en1b
- ID
- ZDB-GENE-980526-6
- Name
- engrailed homeobox 1b
- Symbol
- en1b Nomenclature History
- Previous Names
-
- eng1b
- eng4
- engrailed 4
- wu:fc84e11
- zgc:113499
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Predicted to be active in nucleus. Is expressed in midbrain hindbrain boundary neural keel; myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138514 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3426 | Allele with one point mutation | Unknown | Missense | ENU | |
| nns40Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| nns55Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| nns58Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa100 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa19415 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko127a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko127b | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?ENDOVE syndrome, limb-brain type | 619218 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Engrailed Homeobox Transcription Factors | Homedomain-like superfamily | Homeobox, conserved site | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site | Homeodomain | Homeodomain engrailed | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B3Y5 | InterPro | 278 | ||||||||
| UniProtKB:Q5BJ08 | InterPro | 274 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-252H6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-190D13 | ZFIN Curated Data | |
| Encodes | EST | fc84e11 | ||
| Encodes | EST | IMAGE:7138514 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113499 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192625 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013498 (1) | 1601 nt | ||
| Genomic | GenBank:BX908756 (2) | 134952 nt | ||
| Polypeptide | UniProtKB:A0A8M3B3Y5 (1) | 278 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Labbaf, Z., Petratou, K., Ermlich, L., Backer, W., Tarbashevich, K., Reichman-Fried, M., Luschnig, S., Schulte-Merker, S., Raz, E. (2022) A robust and tunable system for targeted cell ablation in developing embryos. Developmental Cell. 57(16):2026-2040.e5
- Zhou, J., Yang, Y.J., Gan, R.H., Wang, Y., Li, Z., Zhang, X.J., Gui, J.F., Zhou, L. (2022) Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish. Gene expression patterns : GEP. 46:119286
- Sengupta, M., Daliparthi, V., Roussel, Y., Bui, T.V., Bagnall, M.W. (2021) Spinal V1 neurons inhibit motor targets locally and sensory targets distally. Current biology : CB. 31(17):3820-3833.e4
- England, S.J., Cerda, G.A., Kowalchuk, A., Sorice, T., Grieb, G., Lewis, K.E. (2020) Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 216(4):1153-1185
- Wang, G., Muhl, L., Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., van Impel, A. (2020) Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Nature communications. 11:2724
- Zhang, Q., Xu, H., Zhao, W., Zheng, J., Sun, L., Luo, C. (2020) Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing tal1 Transcription in Zebrafish. International Journal of Molecular Sciences. 21(10):
- Hadjivasiliou, Z., Moore, R.E., McIntosh, R., Galea, G.L., Clarke, J.D.W., Alexandre, P. (2019) Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation. Developmental Cell. 49:907-919.e10
- Kimura, Y., Higashijima, S.I. (2019) Regulation of locomotor speed and selection of active sets of neurons by V1 neurons. Nature communications. 10:2268
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
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