Gene
dlx6a
- ID
- ZDB-GENE-980526-448
- Name
- distal-less homeobox 6a
- Symbol
- dlx6a Nomenclature History
- Previous Names
-
- dlx6
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including fin development; neural tube formation; and non-canonical Wnt signaling pathway. Predicted to be active in nucleus. Is expressed in brain; head; and otic vesicle. Orthologous to human DLX6 (distal-less homeobox 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yu et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020833Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| ot503 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa36900 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR2-dlx6a | (2) | |
| MO1-dlx6a | N/A | (3) |
| MO2-dlx6a | N/A | (3) |
| MO3-dlx6a | N/A | Ma et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Distal-less homeobox transcription factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q98877 | InterPro | 247 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(1.1dlx5a-dlx6a:GFP) |
|
| 1 | (2) | |
| Tg(1.4dlx5a-dlx6a:GFP) |
|
| 1 | (3) | |
| Tg(dlx5a-dlx6a:ITETA) |
|
| 4 | (5) | |
| Tg(dlx6a-1.4dlx5a-dlx6a:GFP) |
|
| (35) | ||
| Tg(dlx6a-1.4dlx5a-dlx6a:mCherry) |
|
| 1 | (3) | |
| Tg(dlx6a-dlx5a:GAL4-VP16) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(nccr.i56i-i56ii-dlx6a:GAL4-2A-GFP) |
|
| 1 | Tiraboschi et al., 2020 | |
| Tg(nccr.i56i-i56ii-dlx6a:GFP) |
|
| 1 | (48) | |
| Tg(nccr.i56i-i56ii-dlx6a:KALTA4) |
|
| 1 | Stednitz et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-351F10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136749 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131323 (1) | 1393 nt | ||
| Genomic | GenBank:CU896645 (1) | 162129 nt | ||
| Polypeptide | UniProtKB:Q98877 (1) | 247 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Truong, B.T., Shull, L.C., Lencer, E., Bend, E.G., Field, M., Blue, E.E., Bamshad, M.J., Skinner, C., Everman, D., Schwartz, C.E., Flanagan-Steet, H., Artinger, K.B. (2023) PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation. Disease models & mechanisms. 16(4):
- Yu, E.P.Y., Saxena, V., Perin, S., Ekker, M. (2023) Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology. Biomolecules. 13(9):
- Coltogirone, R.A., Sherfinski, E.I., Dobler, Z.A., Peterson, S.N., Andlinger, A.R., Fadel, L.C., Patrick, R.L., Bergeron, S.A. (2022) Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(3):377-399
- Ma, J., Gu, Y., Liu, J., Song, J., Zhou, T., Jiang, M., Wen, Y., Guo, X., Zhou, Z., Sha, J., He, J., Hu, Z., Luo, L., Liu, M. (2022) Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cellular and molecular life sciences : CMLS. 80:1919
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- Liu, Z., Sun, H., Dai, J., Xue, X., Sun, J., Wang, X. (2021) ITPR1 Mutation Contributes to Hemifacial Microsomia Spectrum. Frontiers in genetics. 12:616329
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Yu, E.P.Y., Perin, S., Saxena, V., Ekker, M. (2021) Novel cross-regulation interactions between dlx genes in larval zebrafish. Gene. 801:145848
- Barske, L., Fabian, P., Hirschberger, C., Jandzik, D., Square, T., Xu, P., Nelson, N., Yu, H.V., Medeiros, D.M., Gillis, J.A., Crump, J.G. (2020) Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Proceedings of the National Academy of Sciences of the United States of America. 117(40):24876-24884
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