Gene
foxa3
- ID
- ZDB-GENE-980526-423
- Name
- forkhead box A3
- Symbol
- foxa3 Nomenclature History
- Previous Names
-
- fa11c04
- fc37a08
- fkd2 (1)
- forkhead-2
- wu:fa11c04
- wu:fc37a08
- zf-FKH1
- Zffkh1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hatching gland development; nervous system development; and neural plate anterior/posterior regionalization. Located in nucleus. Is expressed in several structures, including axial mesoderm; digestive system; endoderm; germ ring; and hatching gland. Orthologous to human FOXA3 (forkhead box A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 180 figures from 150 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb162 | Allele with one deletion | Unknown | Unknown | CRISPR | |
ihb163 | Allele with one deletion | Unknown | Unknown | CRISPR | |
la013319Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 3 of 3
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-foxa3 | Zebrafish Nomenclature Committee | |
CRISPR2-foxa3 | (2) | |
MO1-foxa3 | N/A | (3) |
MO2-foxa3 | N/A | Dal-Pra et al., 2011 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein, C-terminal | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Fork-head N-terminal | Hepatocyte nuclear factor 3-gamma, forkhead domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:O73778 | InterPro | 441 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-223N17 | ZFIN Curated Data | |
Encodes | EST | fa11c04 | ||
Encodes | EST | fc37a08 | ||
Encodes | cDNA | MGC:194053 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194065 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131299 (1) | 2524 nt | ||
Genomic | GenBank:BX908751 (2) | 157961 nt | ||
Polypeptide | UniProtKB:O73778 (1) | 441 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Gang, K., Chen, Q., Sun, J., Zhang, T., Cai, P., Ni, R., Ma, J. (2025) Khdrbs1 drives redifferentiation of bipotential progenitor cell by inhibiting p53 in zebrafish biliary-mediated liver regeneration. Development (Cambridge, England). :
- Jia, K., Cheng, B., Huang, L., Xu, J., Liu, F., Liao, X., Liao, K., Lu, H. (2025) Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration. Development (Cambridge, England). :
- Zhou, W., Cai, W., Li, Y., Gao, L., Liu, X., Liu, S., Lei, J., Zhang, J., Wang, Y., Jiang, Z., Wu, X., Fan, X., Li, F., Zheng, L., Yuan, W. (2025) The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. International Journal of Molecular Sciences. 26:
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):
- Hu, Y., Luo, Z., Wang, M., Wu, Z., Liu, Y., Cheng, Z., Sun, Y., Xiong, J.W., Tong, X., Zhu, Z., Zhang, B. (2024) Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 52(1):66-77
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Jin, Q., Hu, Y., Gao, Y., Zheng, J., Chen, J., Gao, C., Peng, J. (2023) Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish. Biochemical and Biophysical Research Communications. 686:149182149182
- Ma, J., Yang, Z., Huang, Z., Li, L., Huang, J., Chen, J., Ni, R., Luo, L., He, J. (2023) Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology (Baltimore, Md.). 78(1):167-178
- Nagorska, A., Zaucker, A., Lambert, F., Inman, A., Toral-Perez, S., Gorodkin, J., Wan, Y., Smutny, M., Sampath, K. (2023) Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function. Development (Cambridge, England). 150(23):
1 - 10 of 265
Show