Gene
ctslb
- ID
- ZDB-GENE-980526-285
- Name
- cathepsin Lb
- Symbol
- ctslb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in extracellular region. Is expressed in several structures, including hatching gland; hatching gland cell; hypoblast; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L).
- Genome Resources
- Note
-
This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
- Comparative Information
-
- All Expression Data
- 172 figures from 114 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb15 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8E587 | InterPro | 336 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctslb-201
(1)
|
Ensembl | 1,351 nt | ||
| mRNA |
ctslb-203
(1)
|
Ensembl | 1,289 nt | ||
| mRNA |
si:dkey-26g8.4-201
(1)
|
Ensembl | 1,348 nt | ||
| mRNA |
si:dkey-26g8.4-202
(1)
|
Ensembl | 308 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-239J18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-269I1 | ZFIN Curated Data | |
| Encodes | EST | cb15 | Thisse et al., 2001 | |
| Encodes | EST | fb30g09 | ZFIN Curated Data | |
| Encodes | EST | fc13c06 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:123162 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174155 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174856 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC108031 (1) | 1320 nt | ||
| Genomic | GenBank:BX322603 | 191741 nt | ||
| Polypeptide | UniProtKB:A8E587 (1) | 336 aa |
- Comparative Orthology
- Alliance
- Carroll, S.H., Schafer, S., Kawasaki, K., Tsimbal, C., Jule, A.M., Hallett, S.A., Li, E., Liao, E.C. (2024) Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis. eLIFE. 13:
- Chi, W.Y., Lee, G.H., Tang, M.J., Chen, B.H., Lin, W.L., Fu, T.F. (2024) Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation. BMC Biology. 22:146146
- Jones, R.A., Cooper, F., Kelly, G., Barry, D., Renshaw, M.J., Sapkota, G., Smith, J.C. (2024) Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response. Open Biology. 14:240194240194
- Lee, J.J., Wang, T., Wiggins, K., Lu, P.N., Underwood, C., Ochenkowska, K., Samarut, E., Pollard, L.M., Flanagan-Steet, H., Steet, R. (2024) Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders. iScience. 27:109293109293
- McLeod, J.J., Rothschild, S.C., Francescatto, L., Kim, H., Tombes, R.M. (2023) Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):390-403
- Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, H.B., Hui, S.P., Dobreva, G.D., Kikuchi, K., Helker, C.S.M., Stainier, D.Y.R., Mochizuki, N. (2023) Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental Cell. 58(3):224-238.e7
- Boutillon, A., Escot, S., Elouin, A., Jahn, D., González-Tirado, S., Starruß, J., Brusch, L., David, N.B. (2022) Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Developmental Cell. 57(12):1529-1544.e5
- Chernyavskaya, Y., Zhang, X., Liu, J., Blackburn, J. (2022) Long-read sequencing of the zebrafish genome reorganizes genomic architecture. BMC Genomics. 23:116
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Cheng, Y.C., Wu, T.S., Huang, Y.T., Chang, Y., Yang, J.J., Yu, F.Y., Liu, B.H. (2021) Aflatoxin B1 interferes with embryonic liver development: involvement of p53 signaling and apoptosis in zebrafish. Toxicology. 458:152844
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