Gene
myog
- ID
- ZDB-GENE-980526-265
- Name
- myogenin
- Symbol
- myog Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including positive regulation of myoblast fusion; response to activity; and skeletal muscle tissue regeneration. Predicted to be located in nucleus. Is expressed in several structures, including mesoderm; musculature system; myoblast; post-vent region; and trunk. Orthologous to human MYOG (myogenin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 98 figures from 67 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb553 (28 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh265 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| kg125 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| kg128 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| myog_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myog | (2) | |
| MO1-myog | N/A | (3) |
| MO2-myog | N/A | Hinits et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Myogenic factor | Myogenic muscle-specific protein, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:Q9DG26 | InterPro | 256 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-myog | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
7 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myog:EGFP) |
|
| 1 | Nguyen et al., 2017 | |
| Tg(myog:Hsa.HIST1H2BJ-mRFP) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-86H15 | ZFIN Curated Data | |
| Encodes | EST | cb553 | Thisse et al., 2001 | |
| Encodes | EST | fb80e04 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:100763 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131006 (1) | 1384 nt | ||
| Genomic | GenBank:BX537143 (1) | 204606 nt | ||
| Polypeptide | UniProtKB:Q9DG26 (1) | 256 aa |
- Aranda-Martínez, P., Sayed, R.K.A., Fernández-Martínez, J., Ramírez-Casas, Y., Yang, Y., Escames, G., Acuña-Castroviejo, D. (2024) Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. International Journal of Molecular Sciences. 25(11):
- Donaka, R., Zheng, H., Ackert-Bicknell, C.L., Karasik, D. (2024) Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. Gene. 936:149123
- Xia, Z., Tang, B., Li, X., Li, X., Jia, Y., Jiang, J., Chen, J., Song, J., Liu, S., Min, J., Wang, F. (2024) A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese Transporter. Research (Washington, D.C.). 7:04400440
- Zhou, C., Li, M., Sun, Y., Sultan, Y., Li, X. (2024) Systematic Identification of Long Noncoding RNAs during Three Key Organogenesis Stages in Zebrafish. International Journal of Molecular Sciences. 25(6):
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Watson, S., LaVigne, C.A., Xu, L., Surdez, D., Cyrta, J., Calderon, D., Cannon, M.V., Kent, M.R., Silvius, K.M., Kucinski, J.P., Harrison, E.N., Murchison, W., Rakheja, D., Tirode, F., Delattre, O., Amatruda, J.F., Kendall, G.C. (2023) VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis. Cell Reports. 42:112013112013
- Zizioli, D., Codenotti, S., Benaglia, G., Manzoni, M., Massardi, E., Fanzani, A., Borsani, G., Monti, E. (2023) Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development. International Journal of Molecular Sciences. 24(17):
- Hsu, J.Y., Danis, E.P., Nance, S., O'Brien, J.H., Gustafson, A.L., Wessells, V.M., Goodspeed, A.E., Talbot, J.C., Amacher, S.L., Jedlicka, P., Black, J.C., Costello, J.C., Durbin, A.D., Artinger, K.B., Ford, H.L. (2022) SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state. Cell Reports. 38:110323
- Liu, G., Ito, T., Kijima, Y., Yoshitake, K., Asakawa, S., Watabe, S., Kinoshita, S. (2022) Zebrafish Danio rerio myotomal muscle structure and growth from a spatial transcriptomics perspective. Genomics. 114(5):110477
- Sugasawa, T., Komine, R., Manevich, L., Tamai, S., Takekoshi, K., Kanki, Y. (2022) Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle. Nutrients. 14(11)
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