Gene
msx1b
- ID
- ZDB-GENE-980526-26
- Name
- muscle segment homeobox 1b
- Symbol
- msx1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic organ morphogenesis; fin regeneration; and regulation of neuron apoptotic process. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; fin; fin bud; germ ring; and neural crest.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 71 figures from 52 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Phillips et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-msx1b | Sun et al., 2019 | |
| MO1-msx1b | N/A | (2) |
| MO2-msx1b | N/A | Thummel et al., 2006 |
| MO3-msx1b | N/A | Thummel et al., 2006 |
| MO4-msx1b | N/A | Phillips et al., 2006 |
1 - 5 of 5
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa | Msh Homeobox Transcriptional Regulators |
|---|---|---|---|---|---|---|---|
| UniProtKB:B2GSG0 | InterPro | 257 | |||||
| UniProtKB:Q03356 | InterPro | 257 |
1 - 2 of 2
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-msx | monoclonal | IgG1 , k | Mouse |
|
Developmental Studies Hybridoma Bank
|
6 |
1 - 1 of 1
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-6.5msx1b:EGFP) |
|
| 1 | (5) | |
| Tg(msx1b:EGFP) |
|
| 1 | Esteves et al., 2014 |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-80C12 | ZFIN Curated Data | |
| Encodes | EST | fk04h02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110559 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192593 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131260 (1) | 1414 nt | ||
| Genomic | GenBank:CR812943 (2) | 225846 nt | ||
| Polypeptide | UniProtKB:B2GSG0 (1) | 257 aa |
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Moore, J.A., Moreno-Campos, R., Noah, A.S., Singleton, E.W., Uribe, R.A. (2024) BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Benard, E.L., Küçükaylak, I., Hatzold, J., Berendes, K.U.W., Carney, T.J., Beleggia, F., Hammerschmidt, M. (2023) wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(6):566-592
- Cadete, F., Francisco, M., Freitas, R. (2023) Bmp-signaling and the finfold size in zebrafish: implications for the fin-to-limb transition. Evolution; international journal of organic evolution. 77(5):1262-1271
- Shih, H.Y., Chang, C.W., Chen, Y.C., Cheng, Y.C. (2023) Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish. International Journal of Molecular Sciences. 24(2):
- Wang, Y.S., Chen, Y.T., Wu, C.Y. (2023) Functional characterization of stap2b in zebrafish vascular development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23053e23053
- Ha, J., Kim, B.S., Min, B., Nam, J., Lee, J.G., Lee, M., Yoon, B.H., Choi, Y.H., Im, I., Park, J.S., Choi, H., Baek, A., Cho, S.M., Lee, M.O., Nam, K.H., Mun, J.Y., Kim, M., Kim, S.Y., Son, M.Y., Kang, Y.K., Lee, J.S., Kim, J.K., Kim, J. (2022) Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. Science advances. 8:eabk1239
- Laureano, A.S., Flaherty, K., Hinman, A.M., Jadali, A., Nakamura, T., Higashijima, S.I., Sabaawy, H.E., Kwan, K.Y. (2022) shox2 is required for vestibular statoacoustic neuron development. Biology Open. 11(12):
- Leonard, E.V., Figueroa, R.J., Bussmann, J., Lawson, N.D., Amigo, J.D., Siekmann, A.F. (2022) Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signalling for their development. Development (Cambridge, England). 149(7)
- Li, J., Wen, W., Zhang, S., Zhou, C., Feng, Y., Li, X. (2022) The Expression and Function of lincRNA-154324 and the Adjoining Protein-Coding Gene vmp1 in the Caudal Fin Regeneration of Zebrafish. International Journal of Molecular Sciences. 23(16)
1 - 10 of 128
Show