Gene
cdh11
- ID
- ZDB-GENE-980526-170
- Name
- cadherin 11, type 2, OB-cadherin (osteoblast)
- Symbol
- cdh11 Nomenclature History
- Previous Names
-
- cdhvn
- ventral neural cadherin
- vnc
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity and cadherin binding activity. Acts upstream of or within otolith development; retina development in camera-type eye; and retinal ganglion cell axon guidance. Predicted to be located in cell-cell junction and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in cleithrum; nervous system; optic vesicle; and pectoral fin bud. Human ortholog(s) of this gene implicated in Elsahy-Waters syndrome and Teebi hypertelorism syndrome 2. Orthologous to human CDH11 (cadherin 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
el520 | Allele with one deletion | Unknown | Unknown | TALEN | |
mn0010Gt | Transgenic insertion | Unknown | Unknown | DNA | |
sa14413 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27024 | Allele with one point mutation | Unknown | Missense | ENU | |
sa31589 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-cdh11 | Tsai et al., 2020 | |
CRISPR2-cdh11 | Tsai et al., 2020 | |
CRISPR3-cdh11 | Tsai et al., 2020 | |
CRISPR4-cdh11 | Tsai et al., 2020 | |
MO1-cdh11 | N/A | (2) |
MO2-cdh11 | N/A | (4) |
MO3-cdh11 | N/A | (2) |
TALEN1-cdh11 | Askary et al., 2017 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Elsahy-Waters syndrome | Alliance | Elsahy-Waters syndrome | 211380 |
Teebi hypertelorism syndrome 2 | Alliance | Teebi hypertelorism syndrome 2 | 619736 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin, Y-type LIR-motif | Catenin binding domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:B3DGG4 | InterPro | 800 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-155A19 | ZFIN Curated Data | |
Encodes | EST | wz12628 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194061 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194085 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194941 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131214 (1) | 2741 nt | ||
Genomic | GenBank:CT025913 (2) | 192923 nt | ||
Polypeptide | UniProtKB:B3DGG4 (1) | 800 aa |
- Matsumoto, K., Akieda, Y., Haraoka, Y., Hirono, N., Sasaki, H., Ishitani, T. (2024) Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nature communications. 15:1066210662
- Tang, W.J., Watson, C.J., Olmstead, T., Allan, C.H., Kwon, R.Y. (2022) Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration. iScience. 25:103784
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- Kikel-Coury, N.L., Brandt, J.P., Correia, I.A., O'Dea, M.R., DeSantis, D.F., Sterling, F., Vaughan, K., Ozcebe, G., Zorlutuna, P., Smith, C.J. (2021) Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function. PLoS Biology. 19:e3001444
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
- Knüfer, A., Diana, G., Walsh, G.S., Clarke, J.D., Guthrie, S. (2020) Cadherins regulate nuclear topography and function of developing ocular motor circuitry. eLIFE. 9:
- Lu, J., Liu, R., Miao, A., Chen, X., Xiao, W., Wang, Y., Cao, D., Pan, J., Li, L., Luo, Y. (2020) The role of cldnh during the early retinal development in zebrafish. Experimental Eye Research. 200:108207
- Tsai, T.Y., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.P., Megason, S.G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science (New York, N.Y.). 370:113-116
- Kindt, L.M., Coughlin, A.R., Perosino, T.R., Ersfeld, H., Hampton, M., Liang, J.O. (2018) Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing. Genesis (New York, N.Y. : 2000). 56(3):e23096
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
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