Gene
isl1a
- ID
- ZDB-GENE-980526-112
- Name
- ISL LIM homeobox 1a
- Symbol
- isl1a Nomenclature History
- Previous Names
-
- Isl-1 (1)
- isl1
- islet-1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in sinoatrial node cell development. Acts upstream of or within several processes, including endocrine pancreas development; exocrine pancreas development; and neuron differentiation. Located in nucleus. Is expressed in several structures, including heart; mesoderm; nervous system; pancreatic system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 308 figures from 222 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73031 (12 images)
- eu243 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 33 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-isl1a | Han et al., 2020 | |
| MO1-isl1a | N/A | Wan et al., 2006 |
| MO2-isl1a | N/A | (10) |
| MO3-isl1a | N/A | (8) |
| MO4-isl1a | N/A | (5) |
| MO5-isl1a | N/A | Manfroid et al., 2007 |
| MO6-isl1a | N/A | Hoffmann et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Insulin gene enhancer protein ISL-1/2-like | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BCL0 | InterPro | 348 | ||||||
| UniProtKB:A0A8M9PJN3 | InterPro | 257 | ||||||
| UniProtKB:P53405 | InterPro | 349 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-isl | monoclonal | IgG1 | Mouse |
|
Developmental Studies Hybridoma Bank
|
28 | |
| Ab5-isl1 | monoclonal | IgG1 | Mouse |
|
Developmental Studies Hybridoma Bank
|
2 | |
| Ab1-isl1 | polyclonal | IgG | Rabbit |
|
2 | ||
| Ab2-isl | monoclonal | IgG2b | Mouse |
|
Developmental Studies Hybridoma Bank
|
146 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(isl1a:GFP) |
|
| 1 | (16) | |
| Tg(isl1a:GAL4-VP16,UAS:EGFP) |
|
| 1 | (21) | |
| Tg(isl1a:GFP) |
|
| 1 | (231) | |
| Tg(isl1a-hsp70l:trpm7-EGFP) |
|
| Low et al., 2011 | ||
| Tg2(isl1a:GAL4-VP16,14xUAS:KikGR) |
|
| 1 | (2) | |
| Tg2(isl1a-hsp70l:GFP) |
|
| 1 | (4) | |
| Tg(2xNRSE-isl1a-Mmu.Fos:KALTA4,5xUAS-E1B:GAP-YFP-2A-NTR) |
| 2 | (3) | ||
| Tg(2XNRSE-isl1a-Mmu.Fos:KALTA4,5xUAS-E1B:GAP-YFP-2A-NTR_T41Q_N71S_F124T) |
| 2 | Mathias et al., 2014 | ||
| Tg4(isl1a:GFP) |
|
| 1 | (9) | |
| TgBAC(isl1a:GAL4FF) |
|
| 2 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-219F7 | ZFIN Curated Data | |
| Contains | SNP | rs3727897 | Stickney et al., 2002 | |
| Encodes | EST | eu243 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:73031 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130962 (1) | 2275 nt | ||
| Genomic | GenBank:AL954694 (2) | 88466 nt | ||
| Polypeptide | UniProtKB:P53405 (1) | 349 aa |
- Liu, Y., Zhu, Y., Wang, X., Li, Y., Yang, S., Li, H., Dong, B., Wang, Z., Song, Y., Xu, J., Xue, C. (2025) Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos. Food research international (Ottawa, Ont.). 200:115502115502
- Abate, G., Pezzotta, A., Pucci, M., Bortolotto, V., Ribaudo, G., Bonini, S.A., Mastinu, A., Maccarinelli, G., Ongaro, A., Tirelli, E., Zizioli, D., Gianoncelli, A., Memo, M., Grilli, M., Uberti, D. (2024) The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models. Antioxidants (Basel, Switzerland). 13(8):
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Ding, S., Aziz, T., Meng, A., Jia, S. (2024) Aagab is required for zebrafish larval development by regulating neural activity. Journal of genetics and genomics = Yi chuan xue bao. 51(6):630-641
- Gurung, S., Restrepo, N.K., Anand, S.K., Sittaramane, V., Sumanas, S. (2024) Requirement of a novel gene, drish, in the zebrafish retinal ganglion cell and primary motor axon development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):750-770
- Mingardo, E., Kalanithy, J.C., Dworschak, G., Ishorst, N., Yilmaz, Ö., Lindenberg, T., Hollstein, R., Felger, T., Angrand, P.O., Reutter, H., Odermatt, B. (2024) EZH2 specifically regulates ISL1 during embryonic urinary tract formation. Scientific Reports. 14:2290922909
- Roychaudhury, A., Lee, Y.R., Choi, T.I., Thomas, M.G., Kahn, T.N., Yousaf, H., Skinner, C., Maconachie, G., Crosier, M., Horak, H., Constantinescu, C.S., Kim, T.Y., Lee, K.H., Kyung, J.J., Wang, T., Ku, B., Chodirker, B.N., Hammer, M.F., Gottlob, I., Norton, W.H.J., Gorlei, R., Kim, H.G., Graziano, C., Pippucci, T., Lovino, E., Montanari, F., Severi, G., Toro, C., Boerkoel, C.F., Cha, H.S., Choi, C.Y., Kim, S., Yoon, J.Y., Gilmore, K., Vora, N.L., Davis, E.E., Chudley, A.E., Schwartz, C.E., and Kim, C.H. (2024) SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability. Annals of neurology. 96(5):914-931
- Ryu, J.H., Kim, M., Kim, A., Ro, H., Kim, S.H., Yeo, S.Y. (2024) Zebrafish PEX1 Is Required for the Generation of GABAergic Neuron in p3 Domain. Development & reproduction. 28:129139129-139
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
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