Gene
sox19a
- ID
- ZDB-GENE-980526-102
- Name
- SRY-box transcription factor 19a
- Symbol
- sox19a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Contributes to DNA-binding transcription factor activity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; central nervous system; neural rod; presumptive diencephalon; and presumptive structure. Orthologous to human SOX15 (SRY-box transcription factor 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb799 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sox19a | (2) | |
| CRISPR2-sox19a | (2) | |
| CRISPR3-sox19a | (2) | |
| CRISPR4-sox19a | (2) | |
| CRISPR5-sox19a | (2) | |
| CRISPR6-sox19a | (2) | |
| CRISPR7-sox19a | (2) | |
| CRISPR8-sox19a | (2) | |
| CRISPR9-sox19a | (2) | |
| CRISPR10-sox19a | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | SRY-related HMG-box transcription factor-like | Transcription factor SOX |
|---|---|---|---|---|---|---|
| UniProtKB:P47792 | InterPro | 297 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sox19a-201
(1)
|
Ensembl | 2,170 nt | ||
| ncRNA |
sox19a-002
(1)
|
Ensembl | 629 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-137I24 | ZFIN Curated Data | |
| Contains | SNP | rs3727898 | ZFIN Curated Data | |
| Contains | SNP | rs3727899 | ZFIN Curated Data | |
| Encodes | EST | cb799 | Thisse et al., 2001 | |
| Encodes | EST | fc66c01 | ||
| Encodes | cDNA | MGC:100784 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130908 (1) | 2181 nt | ||
| Genomic | GenBank:BX119902 (1) | 170241 nt | ||
| Polypeptide | UniProtKB:P47792 (1) | 297 aa |
- Dai, X., Pradhan, A., Liu, J., Liu, R., Zhai, G., Zhou, L., Dai, J., Shao, F., Yuan, Z., Wang, Z., Yin, Z. (2023) Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions. Biology of sex differences. 14:5353
- Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685
- Yuikawa, T., Sato, T., Ikeda, M., Tsuruoka, M., Yasuda, K., Sato, Y., Nasu, K., Yamasu, K. (2023) Elongation of the developing spinal cord is driven by Oct4-type transcription factor-mediated regulation of retinoic acid signaling in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):404-422
- Gao, M., Veil, M., Rosenblatt, M., Riesle, A.J., Gebhard, A., Hass, H., Buryanova, L., Yampolsky, L.Y., Grüning, B., Ulianov, S.V., Timmer, J., Onichtchouk, D. (2022) Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nature communications. 13:788
- Michel, L., Palma, K., Cerda, M., Lagadec, R., Mayeur, H., Fuentès, M., Besseau, L., Martin, P., Magnanou, E., Blader, P., Concha, M.L., Mazan, S. (2022) Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel. Frontiers in cell and developmental biology. 10:1015074
- Okada, K., Aoki, K., Tabei, T., Sugio, K., Imai, K., Bonkohara, Y., Kamachi, Y. (2022) Key sequence features of CRISPR RNA for dual-guide CRISPR-Cas9 ribonucleoprotein complexes assembled with wild-type or HiFi Cas9. Nucleic acids research. 50(5):2854-2871
- Ogita, Y., Tamura, K., Mawaribuchi, S., Takamatsu, N., Ito, M. (2021) Independent pseudogenizations and losses of sox15 during amniote diversification following asymmetric ohnolog evolution. BMC ecology and evolution. 21:134
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Yuikawa, T., Ikeda, M., Tsuda, S., Saito, S., Yamasu, K. (2021) Involvement of Oct4-type transcription factor Pou5f3 in posterior spinal cord formation in zebrafish embryos. Development, growth & differentiation. 63(6):306-322
- Zafar, I., Iftikhar, R., Ahmad, S.U., Rather, M.A. (2021) Genome wide identification, phylogeny, and synteny analysis of sox gene family in common carp (Cyprinus carpio). Biotechnology reports (Amsterdam, Netherlands). 30:e00607
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