Gene
shtn1
- ID
- ZDB-GENE-121127-1
- Name
- shootin 1
- Symbol
- shtn1 Nomenclature History
- Previous Names
-
- gb:bc139653 (1)
- si:ch73-56p18.4
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within posterior lateral line neuromast primordium migration. Predicted to be located in several cellular components, including growth cone; lamellipodium; and perikaryon. Predicted to be part of microtubule associated complex. Predicted to be active in axonal growth cone; cell leading edge; and cytoplasm. Is expressed in nervous system and optic vesicle. Orthologous to human SHTN1 (shootin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Urasaki et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ni101 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa9054 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42913 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42914 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44871 | Allele with one point mutation | Unknown | Unknown | ENU | |
| syu203 | Allele with one insertion | Exon 4 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-shtn1 | Urasaki et al., 2019 | |
| CRISPR2-shtn1 | Urasaki et al., 2019 | |
| CRISPR3-shtn1 | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR024849 | Shootin-1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Shootin-1 |
|---|---|---|---|
| UniProtKB:Q6P0R8 | InterPro | 544 | |
| UniProtKB:A0A8M9PE57 | InterPro | 443 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-36G21 | ZFIN Curated Data | |
| Contained in | BAC | CH73-56P18 | ZFIN Curated Data | |
| Has Artifact | EST | fj79f04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001198761 (1) | 1904 nt | ||
| Genomic | GenBank:BX649351 (1) | 144569 nt | ||
| Polypeptide | UniProtKB:Q6P0R8 (1) | 544 aa |
- Tang, S.L., Liang, X.F., He, S., Li, L., Alam, M.S., Wu, J. (2022) Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Frontiers in genetics. 13:909091
- Emerson, S.E., Stergas, H.R., Bupp-Chickering, S.O., Ebert, A.M. (2020) Shootin-1 Is Required for Nervous System Development in Zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(10):1285-1295
- Urasaki, A., Morishita, S., Naka, K., Uozumi, M., Abe, K., Huang, L., Watase, E., Nakagawa, O., Kawakami, K., Matsui, T., Bessho, Y., Inagaki, N. (2019) Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system. Scientific Reports. 9:12156
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- Madgwick, A., Fort, P., Hanson, P.S., Thibault, P., Gaudreau, M.C., Lutfalla, G., Möröy, T., Abou Elela, S., Chaudhry, B., Elliott, D.J., Morris, C.M., Venables, J.P. (2015) Neural Differentiation Modulates the Vertebrate Brain Specific Splicing Program. PLoS One. 10:e0125998
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