Gene
svep1
- ID
- ZDB-GENE-110726-1
- Name
- sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
- Symbol
- svep1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including epidermal cell differentiation; epithelial cell-cell adhesion; and lymph vessel morphogenesis. Predicted to be located in several cellular components, including cytoplasm; extracellular region; and nucleus. Is expressed in fin bud; pharyngeal arch 3-7; and trunk. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kärpanen et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu4767 | Allele with one point mutation | Exon 14 | Premature Stop | ENU | |
| hu6123 | Allele with one point mutation | Exon 4 | Premature Stop | ENU | |
| hu6985 | Allele with one point mutation | Exon 35 | Premature Stop | ENU | |
| ncv106 | Allele with one deletion | Unknown | Unknown | TALEN | |
| sa1285 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9584 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12993 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17476 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20926 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31569 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-svep1 | N/A | (2) |
| MO2-svep1 | N/A | Samuelov et al., 2017 |
| TALEN1-svep1 | Morooka et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement & Cell Adhesion Regulators | Concanavalin A-like lectin/glucanase domain superfamily | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | HYR domain | Pentraxin-related | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily | Tyrosine-protein kinase ephrin type A/B receptor-like | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QHN0 | InterPro | 3526 | ||||||||||||||||
| UniProtKB:A0A8M3AU46 | InterPro | 2217 | ||||||||||||||||
| UniProtKB:A0A8M3BAY6 | InterPro | 3558 | ||||||||||||||||
| UniProtKB:A0A8M3B423 | InterPro | 1869 | ||||||||||||||||
| UniProtKB:A0A8M9Q8H8 | InterPro | 3583 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(svep1:GAL4FF) |
|
| 1 | (3) | |
| TgBAC(svep1:mCherry) |
|
| 1 | Morooka et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-216P19 | ||
| Contained in | BAC | DKEY-11K2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-97O7 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_690650 (1) | 11644 nt | ||
| Genomic | GenBank:CR318603 (1) | 188703 nt | ||
| Polypeptide | UniProtKB:A0A1D5NSM8 (1) | 3615 aa |
- Comparative Orthology
- Alliance
- Hußmann, M., Schulte, D., Weischer, S., Carlantoni, C., Nakajima, H., Mochizuki, N., Stainier, D.Y.R., Zobel, T., Koch, M., Schulte-Merker, S. (2023) Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner. eLIFE. 12:
- Coxam, B., Collins, R.T., Hußmann, M., Huisman, Y., Meier, K., Jung, S., Bartels-Klein, E., Szymborska, A., Finotto, L., Helker, C.S.M., Stainier, D.Y.R., Schulte-Merker, S., Gerhardt, H. (2022) Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions. Development (Cambridge, England). 149(6):
- Peng, D., Ando, K., Hußmann, M., Gloger, M., Skoczylas, R., Mochizuki, N., Betsholtz, C., Fukuhara, S., Schulte-Merker, S., Lawson, N.D., Koltowska, K. (2022) Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. eLIFE. 11
- Szenker-Ravi, E., Ott, T., Khatoo, M., de Bellaing, A.M., Goh, W.X., Chong, Y.L., Beckers, A., Kannesan, D., Louvel, G., Anujan, P., Ravi, V., Bonnard, C., Moutton, S., Schoen, P., Fradin, M., Colin, E., Megarbane, A., Daou, L., Chehab, G., Di Filippo, S., Rooryck, C., Deleuze, J.F., Boland, A., Arribard, N., Eker, R., Tohari, S., Ng, A.Y., Rio, M., Lim, C.T., Eisenhaber, B., Eisenhaber, F., Venkatesh, B., Amiel, J., Crollius, H.R., Gordon, C.T., Gossler, A., Roy, S., Attie-Bitach, T., Blum, M., Bouvagnet, P., Reversade, B. (2021) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nature Genetics. 54(1):62-72
- Wang, G., Muhl, L., Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., van Impel, A. (2020) Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Nature communications. 11:2724
- Kärpanen, T., Padberg, Y., van de Pavert, S.A., Dierkes, C., Morooka, N., Peterson-Maduro, J., van de Hoek, G., Adrian, M., Mochizuki, N., Sekiguchi, K., Kiefer, F., Schulte, D., Schulte-Merker, S. (2017) An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circulation research. 120(8):1263-1275
- Morooka, N., Futaki, S., Sato-Nishiuchi, R., Nishino, M., Totani, Y., Shimono, C., Nakano, I., Nakajima, H., Mochizuki, N., Sekiguchi, K. (2017) Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circulation research. 120:1276-1288
- Samuelov, L., Li, Q., Bochner, R., Najor, N., Albrecht, L., Malchin, N., Goldsmith, T., Grafi-Cohen, M., Vodo, D., Fainberg, G., Meilik, B., Goldberg, I., Warshauer, E., Rogers, T., Edie, S., Ishida-Yamamoto, A., Burzenski, L., Erez, N., Murray, S.A., Irvine, A.D., Shultz, L., Green, K., Uitto, J., Sprecher, E., Sarig, O. (2017) SVEP1 plays a crucial role in epidermal differentiation. Experimental dermatology. 26(5):423-430
- Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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