Gene
dkk3a
- ID
- ZDB-GENE-110519-1
- Name
- dickkopf WNT signaling pathway inhibitor 3a
- Symbol
- dkk3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within regulation of protein stability. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in head; nervous system; otic vesicle; and somite. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dickkopf, N-terminal cysteine-rich | Dickkopf related protein 1-4 | Dickkopf-related protein 3, second cysteine-rich domain |
|---|---|---|---|---|---|
| UniProtKB:C1K6H6 | InterPro | 293 |
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- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-dkk3 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
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Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001159283 (1) | 950 nt | ||
| Genomic | GenBank:CABZ01012411 (1) | 35577 nt | ||
| Polypeptide | UniProtKB:C1K6H6 (1) | 293 aa |
- Chiang, C.Y., Ching, Y.H., Chang, T.Y., Hu, L.S., Yong, Y.S., Keak, P.Y., Mustika, I., Lin, M.D., Liao, B.Y. (2019) Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome. Computational and structural biotechnology journal. 18:73-82
- Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
- Ramachandran, R., Zhao, X.F., and Goldman, D. (2012) Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Nature cell biology. 14(10):1013-1023
- Hsu, R.J., Lin, C.C., Su, Y.F., and Tsai, H.J. (2011) dickkopf-3-related Gene Regulates the Expression of Zebrafish myf5 Gene through Phosphorylated p38a-dependent Smad4 Activity. The Journal of biological chemistry. 286(8):6855-6864
- Ramachandran, R., Zhao, X.F., and Goldman, D. (2011) Ascl1a/Dkk/ beta -catenin signaling pathway is necessary and glycogen synthase kinase-3 beta inhibition is sufficient for zebrafish retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 108(38):15858-63
- Untergasser, G., Martowicz, A., Hermann, M., Töchterle, S., and Meyer, D. (2011) Distinct expression patterns of dickkopf genes during late embryonic development of Danio rerio. Gene expression patterns : GEP. 11(8):491-500
- Hsu, R.J., Lin, C.Y., Hoi, H.S., Zheng, S.K., Lin, C.C., and Tsai, H.J. (2010) Novel intronic microRNA represses zebrafish myf5 promoter activity through silencing dickkopf-3 gene. Nucleic acids research. 38(13):4384-4393
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