Gene
wdpcp
- ID
- ZDB-GENE-100405-4
- Name
- WD repeat containing planar cell polarity effector
- Symbol
- wdpcp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to be involved in cilium organization; establishment of protein localization; and nervous system development. Predicted to act upstream of or within cell projection organization. Predicted to be located in several cellular components, including cilium; cytoskeleton; and plasma membrane. Predicted to be active in axonemal basal plate. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 15 and congenital heart defects, hamartomas of tongue, and polysyndactyly. Orthologous to human WDPCP (WD repeat containing planar cell polarity effector).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Collins et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Phenotype Annotation (1994-2006)
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh348 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh349 | Allele with one point mutation | Unknown | Unknown | ENU | |
| j101e1 | unknown | Unknown | Unknown | not specified | |
| sa13922 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23077 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39162 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| wdpcp_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bardet-Biedl syndrome 15 | Alliance | Bardet-Biedl syndrome 15 | 615992 |
| congenital heart defects, hamartomas of tongue, and polysyndactyly | Alliance | Congenital heart defects, hamartomas of tongue, and polysyndactyly | 217085 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat-containing and planar cell polarity effector protein Fritz |
|---|---|---|---|---|---|
| UniProtKB:E7F9Q9 | InterPro | 707 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207O18 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-74F1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214588 (1) | 2592 nt | ||
| Genomic | GenBank:BX649529 (1) | 216647 nt | ||
| Polypeptide | UniProtKB:E7F9Q9 (1) | 707 aa |
- Comparative Orthology
- Alliance
- Collins, M.M., Maischein, H.M., Dufourcq, P., Charpentier, M., Blader, P., Stainier, D.Y. (2018) Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration. eLIFE. 7:
- Dragojević, J., Mihaljević, I., Popović, M., Zaja, R., Smital, T. (2018) In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Toxicology in vitro : an international journal published in association with BIBRA. 46:246-256
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Parichy, D.M. and Johnson, S.L. (2001) Zebrafish hybrids suggest genetic mechanisms for pigment pattern diversification in Danio. Development genes and evolution. 211(7):319-328
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