havcr2

ID

ZDB-GENE-091204-20

Name

hepatitis A virus cellular receptor 2

Symbol

havcr2 Nomenclature History

Previous Names

DrTIM-3 (1)
kim1 (1)
si:dkey-222k23.2 (1)
tim3 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable phosphatidylserine binding activity. Predicted to be involved in apoptotic cell clearance and cytoskeletal rearrangement involved in phagocytosis, engulfment. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; renal cell carcinoma; and subcutaneous panniculitis-like T-cell lymphoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Yin et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With havcr2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
subcutaneous panniculitis-like T-cell lymphoma	Alliance	T-cell lymphoma, subcutaneous panniculitis-like	618398

Associated With havcr2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily