Gene

apela

ID
ZDB-GENE-090313-116
Name
apelin receptor early endogenous ligand
Symbol
apela Nomenclature History
Previous Names
  • ela
  • tdl
  • elabela (1)
  • ende
  • linc_tmem192 (1)
  • si:ch211-42i9.4
  • toddler
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Enables apelin receptor binding activity and hormone activity. Involved in apelin receptor signaling pathway; gastrulation; and heart development. Acts upstream of with a positive effect on Kupffer's vesicle development. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within blood vessel morphogenesis; chordate embryonic development; and gastrulation. Located in extracellular space. Is expressed in several structures, including Kupffer's vesicle; axis; heart primordium; hypoblast; and mesoderm. Orthologous to human APELA (apelin receptor early endogenous ligand).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
29 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
a141Allele with one deletionUnknownFrameshiftTALEN
a142Allele with one delinsUnknownFrameshiftTALEN
la011777TgTransgenic insertionUnknownUnknownDNA
vbc23Allele with one deletionExon 1UnknownTALEN
zf438Allele with one deletionUnknownUnknownzinc finger nuclease
zf439Allele with one deletionUnknownFrameshiftzinc finger nuclease
zf440Allele with one deletionUnknownFrameshiftzinc finger nuclease
zko378aAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
1 - 8 of 8
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Human Disease
Associated With apela Human Ortholog
No data available
Associated With apela Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR047853 Apelin receptor early endogenous ligand
1 - 1 of 1
Domain Details Per Protein
Protein Additional Resources Length Apelin receptor early endogenous ligand
UniProtKB:P0DMC2 InterPro
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA apela-201 (1) Ensembl 748 nt
mRNA apela-202 (1) Ensembl 867 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(hsp70l:apela,myl7:EGFP)
  • Danio rerio
1 (2)
1 - 1 of 1
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-42I9ZFIN Curated Data
1 - 1 of 1
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanAPELA4
Amino acid sequence comparison (2)
MouseApela8
Amino acid sequence comparison (2)
Citations
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