Gene
apela
- ID
- ZDB-GENE-090313-116
- Name
- apelin receptor early endogenous ligand
- Symbol
- apela Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables apelin receptor binding activity and hormone activity. Involved in apelin receptor signaling pathway; gastrulation; and heart development. Acts upstream of with a positive effect on Kupffer's vesicle development. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within blood vessel morphogenesis; chordate embryonic development; and gastrulation. Located in extracellular space. Is expressed in several structures, including Kupffer's vesicle; axis; heart primordium; hypoblast; and mesoderm. Orthologous to human APELA (apelin receptor early endogenous ligand).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
a141 | Allele with one deletion | Unknown | Frameshift | TALEN | |
a142 | Allele with one delins | Unknown | Frameshift | TALEN | |
la011777Tg | Transgenic insertion | Unknown | Unknown | DNA | |
vbc23 | Allele with one deletion | Exon 1 | Unknown | TALEN | |
zf438 | Allele with one deletion | Unknown | Unknown | zinc finger nuclease | |
zf439 | Allele with one deletion | Unknown | Frameshift | zinc finger nuclease | |
zf440 | Allele with one deletion | Unknown | Frameshift | zinc finger nuclease | |
zko378a | Allele with one deletion | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-apela | Zhu et al., 2019 | |
CRISPR2-apela | Zhu et al., 2019 | |
CRISPR3-apela | Zhu et al., 2019 | |
CRISPR4-apela | Zhu et al., 2019 | |
CRISPR5-apela | Sun et al., 2019 | |
CRISPR6-apela | Sun et al., 2019 | |
MO1-apela | N/A | (2) |
TALEN1-apela | (5) |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR047853 | Apelin receptor early endogenous ligand |
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Domain Details Per Protein
Protein | Additional Resources | Length | Apelin receptor early endogenous ligand |
---|---|---|---|
UniProtKB:P0DMC2 | InterPro |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-42I9 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001297547 (1) | |||
Genomic | GenBank:BX323590 (1) | 162630 nt | ||
Polypeptide | UniProtKB:P0DMC2 (2) |
- Nys, N., Khatib, A.M., Siegfried, G. (2024) Apela promotes blood vessel regeneration and remodeling in zebrafish. Scientific Reports. 14:37183718
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
- Stock, J., Kazmar, T., Schlumm, F., Hannezo, E., Pauli, A. (2022) A self-generated Toddler gradient guides mesodermal cell migration. Science advances. 8:eadd2488
- Helker, C.S., Eberlein, J., Wilhelm, K., Sugino, T., Malchow, J., Schuermann, A., Baumeister, S., Kwon, H.B., Maischein, H.M., Potente, M., Herzog, W., Stainier, D.Y. (2020) Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. eLIFE. 9:e55589
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Zhu, C., Guo, Z., Zhang, Y., Liu, M., Chen, B., Cao, K., Wu, Y., Yang, M., Yin, W., Zhao, H., Tai, H., Ou, Y., Yu, X., Liu, C., Li, S., Su, B., Feng, Y., Huang, S. (2019) Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms. International journal of biological sciences. 15:1225-1239
- Zhang, J., Wan, Y., Fang, C., Chen, J., Ouyang, W., Li, J., Wang, Y. (2018) The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates. Biochemical and Biophysical Research Communications. 501(2):408-414
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Hurem, S., Martín, L.M., Lindeman, L., Brede, D.A., Salbu, B., Lyche, J.L., Aleström, P., Kamstra, J.H. (2017) Parental exposure to gamma radiation causes progressively altered transcriptomes linked to adverse effects in zebrafish offspring. Environmental pollution (Barking, Essex : 1987). 234:855-863
- Lu, L., Cao, J., Li, L., Chen, L. (2017) Elabela, a new endogenous ligand of APJ, functions in embryos and adults organisms. Acta biochimica et biophysica Sinica. 49:378-381
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