Gene

gper1

ID
ZDB-GENE-090311-1
Name
G protein-coupled estrogen receptor 1
Symbol
gper1 Nomenclature History
Previous Names
  • gper
  • gpr30
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Enables G protein-coupled estrogen receptor activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; negative regulation of oocyte maturation; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; regulation of vitellogenesis; and swimming behavior. Located in plasma membrane. Is expressed in several structures, including blastomere; liver; nervous system; olfactory region; and pleuroperitoneal region. Orthologous to human GPER1 (G protein-coupled estrogen receptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ecu18Allele with one deletionUnknownUnknownTALEN
ihb374Allele with one deletionExon 2UnknownCRISPR
ihb499Allele with one insertionExon 2UnknownCRISPR
la028931TgTransgenic insertionUnknownUnknownDNA
uab102Allele with one deletionUnknownPremature StopCRISPR
ulg080Allele with one deletionExon 3Frameshift, Premature StopCRISPR
umo40Allele with one deletionUnknownPremature StopCRISPR
zf2223Allele with one deletionExon 1Premature StopTALEN
zf3755Allele with one delinsExon 3UnknownCRISPR
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Sequence Targeting Reagents
Human Disease
Associated With gper1 Human Ortholog
No data available
Associated With gper1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR047143 G-protein coupled estrogen receptor 1-like
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Domain Details Per Protein
Protein Additional Resources Length GPCR, rhodopsin-like, 7TM G-protein coupled estrogen receptor 1-like G protein-coupled receptor, rhodopsin-like
UniProtKB:B3G515 InterPro 353
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gper1-201 (1) Ensembl 2,636 nt
mRNA gper1-202 (1) Ensembl 2,816 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gper polyclonal Rabbit
  • IHC
1
Ab2-gper1 polyclonal Rabbit
  • WB
1
Ab3-gper1 polyclonal Rabbit
  • WB
Sigma-Aldrich
2
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(gper1:EGFP)
  • gper1
  • Danio rerio
1Wang et al., 2019
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-24P6ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGPER17
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Phylogenetic tree (1)
Nucleotide sequence comparison (1)
MouseGper15
Amino acid sequence comparison (1)
Citations
1 - 10 of 36
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