Gene
gper1
- ID
- ZDB-GENE-090311-1
- Name
- G protein-coupled estrogen receptor 1
- Symbol
- gper1 Nomenclature History
- Previous Names
-
- gper
- gpr30
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables G protein-coupled estrogen receptor activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; negative regulation of oocyte maturation; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; regulation of vitellogenesis; and swimming behavior. Located in plasma membrane. Is expressed in several structures, including blastomere; liver; nervous system; olfactory region; and pleuroperitoneal region. Orthologous to human GPER1 (G protein-coupled estrogen receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ecu18 | Allele with one deletion | Unknown | Unknown | TALEN | |
| ihb374 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihb499 | Allele with one insertion | Exon 2 | Unknown | CRISPR | |
| la028931Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| uab102 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| ulg080 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| umo40 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| zf2223 | Allele with one deletion | Exon 1 | Premature Stop | TALEN | |
| zf3755 | Allele with one delins | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gper1 | (3) | |
| CRISPR2-gper1 | (3) | |
| CRISPR3-gper1 | Zebrafish Nomenclature Committee | |
| CRISPR4-gper1 | Li et al., 2022 | |
| CRISPR5-gper1 | Zebrafish Nomenclature Committee | |
| CRISPR6-gper1 | (2) | |
| MO1-gper1 | N/A | (2) |
| MO2-gper1 | N/A | Shi et al., 2013 |
| MO3-gper1 | N/A | Chaturantabut et al., 2019 |
| MO4-gper1 | N/A | Chaturantabut et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled estrogen receptor 1-like | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:B3G515 | InterPro | 353 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gper1:EGFP) |
|
| 1 | Wang et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24P6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128723 (1) | 2833 nt | ||
| Genomic | GenBank:CR382361 (1) | 61415 nt | ||
| Polypeptide | UniProtKB:B3G515 (1) | 353 aa |
- Guerrero-Limón, G., Muller, M. (2024) Exploring Estrogen antagonism using CRISPR/Cas9 to generate specific mutants for each of the receptors. Chemosphere. 364:143100
- Li, X., Wang, L., Qin, X., Chen, X., Li, L., Huang, Z., Zhang, W., Liu, W. (2022) Estrogens revert neutrophil hyperplasia by inhibiting Hif1α-cMyb pathway in zebrafish myelodysplastic syndromes models. Cell death discovery. 8:323
- Meng, Q., Yeung, K., Chan, K.M. (2021) Toxic effects of octocrylene on zebrafish larvae and liver cell line (ZFL). Aquatic toxicology (Amsterdam, Netherlands). 236:105843
- Wu, X.J., Williams, M.J., Kew, K.A., Converse, A., Thomas, P., Zhu, Y. (2021) Reduced Vitellogenesis and Female Fertility in Gper Knockout Zebrafish. Frontiers in endocrinology. 12:637691
- Huang, W., Ai, W., Lin, W., Fang, F., Wang, X., Huang, H., Dahlgren, R.A., Wang, H. (2020) Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism. Ecotoxicology and environmental safety. 204:111068
- Liu, S., Chen, F., Zhang, Y., Cai, L., WenhuiQiu, ., Yang, M. (2020) G protein-coupled estrogen receptor 1 mediates estrogen effect in red common carp (Cyprinus carpio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 239:108868
- Meng, Q., Yeung, K., Kwok, M.L., Chung, C.T., Hu, X.L., Chan, K.M. (2020) Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones. Environmental pollution (Barking, Essex : 1987). 265:114857
- Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
- Chen, Y., Tang, H., He, J., Xi, W., Le, W., Liu, X., Lin, H. (2019) Interaction of nuclear ERs and GPER in vitellogenesis in zebrafish. The Journal of steroid biochemistry and molecular biology. 189:10-18
- González-Rojo, S., Lombó, M., Fernández-Díez, C., Herráez, M.P. (2019) Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes. Environmental pollution (Barking, Essex : 1987). 248:368-379
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