Gene
sox6
- ID
- ZDB-GENE-081120-6
- Name
- SRY-box transcription factor 6
- Symbol
- sox6 Nomenclature History
- Previous Names
-
- sox6b (1)
- fc35a10
- fc50e03
- wu:fc35a10
- wu:fc50e03
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within adipose tissue development; muscle cell fate specification; and skeletal muscle tissue development. Predicted to be active in nucleus. Is expressed in intermuscular bone; muscle; pharyngeal arch 3-7; somite; and telencephalon. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX6 (SRY-box transcription factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
i291 | unknown | Unknown | Unknown | zinc finger nuclease | |
i292 | unknown | Unknown | Unknown | zinc finger nuclease | |
la016058Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la016060Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la025941Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa9376 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20951 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38612 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa44663 | Allele with one point mutation | Unknown | Unknown | ENU | |
sa45277 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Tolchin-Le Caignec syndrome | 618971 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | SOX/SOX-like transcription factors |
---|---|---|---|---|---|
UniProtKB:B2CNY6 | InterPro | ||||
UniProtKB:F8W2H3 | InterPro | 768 | |||
UniProtKB:A0A8M1NI90 | InterPro | 785 | |||
UniProtKB:A0AB32TRN6 | InterPro | 816 | |||
UniProtKB:A0AB32TRQ1 | InterPro | 817 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg1(-2.8sox6:EGFP-UTR-sox6) |
|
| 1 | (3) | |
Tg(-1.5sox6:EGFP) |
|
| 1 | (3) | |
Tg2(-2.8sox6:EGFP-UTR-sox6) |
|
| 1 | (3) | |
Tg(-2.8sox6:EGFP) |
|
| 1 | (3) | |
Tg(-2.8sox6:mCherry) |
|
| 1 | (3) | |
Tg(-2sox6:EGFP) |
|
| 1 | (3) | |
Tg3(-2.8sox6:EGFP-UTR-sox6) |
|
| 1 | (3) | |
Tg(-7.6sox6:EGFP) |
|
| 1 | (6) | |
Tg(sox6:mCherry) |
|
| 1 | (3) | |
Tg(UAS:sox6-EGFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-48H11 | ZFIN Curated Data | |
Contained in | BAC | DKEY-246O4 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-93A2 | ZFIN Curated Data | |
Encodes | EST | fc35a10 | ||
Encodes | EST | fc50e03 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001123009 (1) | 8175 nt | ||
Genomic | GenBank:BX537340 (2) | 192070 nt | ||
Polypeptide | UniProtKB:A0AB32TWV8 (1) | 837 aa |
- Donaka, R., Zheng, H., Ackert-Bicknell, C.L., Karasik, D. (2024) Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. Gene. 936:149123
- Niu, M., Whang, H., Wu, Z., ShouwenJiang, ., Chen, L. (2024) The deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone. Gene. 923:148561
- Fabian, P., Tseng, K.C., Thiruppathy, M., Arata, C., Chen, H.J., Smeeton, J., Nelson, N., Crump, J.G. (2022) Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nature communications. 13:13
- Tian, Y., Wang, W., Lautrup, S., Zhao, H., Li, X., Law, P.W.N., Dinh, N.D., Fang, E.F., Cheung, H.H., Chan, W.Y. (2022) WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nature communications. 13:5456
- Hoffmann, S., Roeth, R., Diebold, S., Gogel, J., Hassel, D., Just, S., Rappold, G.A. (2021) Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. Frontiers in genetics. 12:688808
- Keller, R.M., Beaver, L.M., Reardon, P.N., Prater, M.C., Truong, L., Robinson, M.M., Tanguay, R.L., Stevens, J.F., Hord, N.G. (2021) Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish skeletal muscle. Journal of applied physiology (Bethesda, Md. : 1985). 131(1):142-157
- Zafar, I., Iftikhar, R., Ahmad, S.U., Rather, M.A. (2021) Genome wide identification, phylogeny, and synteny analysis of sox gene family in common carp (Cyprinus carpio). Biotechnology reports (Amsterdam, Netherlands). 30:e00607
- Huang, X., Wu, C., Gong, K., Chen, Q., Gu, Q., Qin, H., Zhao, C., Yu, T., Yang, L., Fu, W., Wang, Y., Qin, Q., Liu, S. (2020) Sox Gene Family Revealed Genetic Variations in Autotetraploid Carassius auratus. Frontiers in genetics. 11:804
- Ciano, M., Mantellato, G., Connolly, M., Paul-Clark, M., Willis-Owen, S., Moffatt, M.F., Cookson, W.O.C.M., Mitchell, J.A., Polkey, M.I., Hughes, S.M., Kemp, P.R., Natanek, S.A. (2019) EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype. Scientific Reports. 9:9218
- Lin, S., Lin, X., Zhang, Z., Jiang, M., Rao, Y., Nie, Q., Zhang, X. (2018) Copy Number Variation in SOX6 Contributes to Chicken Muscle Development. Genes. 9(1)
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