Gene

cdkn2a/b

ID
ZDB-GENE-081104-306
Name
cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
Symbol
cdkn2a/b Nomenclature History
Previous Names
  • cdkn2b
  • ink4b (1)
  • p16 (1)
  • si:dkey-123o10.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of cell population proliferation and regulation of G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in digestive system; eye; heart; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A) and CDKN2B (cyclin dependent kinase inhibitor 2B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ou3007TgTransgenic insertionUnknownUnknownDNA and CRISPR
sa25583Allele with one point mutationUnknownSplice SiteENU
sa32685Allele with one point mutationUnknownPremature StopENU
zk1Allele with one deletionExon 1FrameshiftTALEN
zk2Allele with one deletionExon 1FrameshiftTALEN
1 - 5 of 5
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Sequence Targeting Reagents
Human Disease
Associated With cdkn2a/b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
melanoma and neural system tumor syndrome Alliance {Melanoma and neural system tumor syndrome} 155755
{Melanoma, cutaneous malignant, 2} 155601
{Melanoma-pancreatic cancer syndrome} 606719
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Associated With cdkn2a/b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR050776 Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
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Domain Details Per Protein
Protein Additional Resources Length Ankyrin repeat Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor Ankyrin repeat-containing domain superfamily
UniProtKB:E9QFU2 InterPro 125
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cdkn2a/b-201 (1) Ensembl 378 nt
mRNA cdkn2a/b-202 (1) Ensembl 390 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdkn2b monoclonal IgG2a Rat
  • IHC
2
Ab2-cdkn2a polyclonal Rabbit
  • WB
Proteintech
Cell Signaling Technology, Inc.
Sigma-Aldrich
1
1 - 2 of 2
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-145B13ZFIN Curated Data
Contained inBACDKEY-123O10ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCDKN2A9
Amino acid sequence comparison (1)
Conserved genome location (synteny) (2)
HumanCDKN2B9
Amino acid sequence comparison (1)
Conserved genome location (synteny) (2)
MouseCdkn2a4
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseCdkn2b4
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 40
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