Gene
cdkn2a/b
- ID
- ZDB-GENE-081104-306
- Name
- cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
- Symbol
- cdkn2a/b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of cell population proliferation and regulation of G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in digestive system; eye; heart; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A) and CDKN2B (cyclin dependent kinase inhibitor 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ou3007Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
sa25583 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa32685 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zk1 | Allele with one deletion | Exon 1 | Frameshift | TALEN | |
zk2 | Allele with one deletion | Exon 1 | Frameshift | TALEN |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
melanoma and neural system tumor syndrome | Alliance | {Melanoma and neural system tumor syndrome} | 155755 |
{Melanoma, cutaneous malignant, 2} | 155601 | ||
{Melanoma-pancreatic cancer syndrome} | 606719 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor | Ankyrin repeat-containing domain superfamily |
---|---|---|---|---|---|
UniProtKB:E9QFU2 | InterPro | 125 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cdkn2a/b-201
(1)
|
Ensembl | 378 nt | ||
mRNA |
cdkn2a/b-202
(1)
|
Ensembl | 390 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-cdkn2b | monoclonal | IgG2a | Rat |
|
2 | ||
Ab2-cdkn2a | polyclonal | Rabbit |
|
Proteintech
Cell Signaling Technology, Inc. Sigma-Aldrich |
1 |
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Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-145B13 | ZFIN Curated Data | |
Contained in | BAC | DKEY-123O10 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_002660468 (1) | |||
Genomic | GenBank:CT573245 | 196368 nt | ||
Polypeptide | UniProtKB:E9QFU2 (1) | 125 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | CDKN2A | 9 | Amino acid sequence comparison (1) Conserved genome location (synteny) (2) | |
Human | CDKN2B | 9 | Amino acid sequence comparison (1) Conserved genome location (synteny) (2) | |
Mouse | Cdkn2a | 4 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) | |
Mouse | Cdkn2b | 4 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) |
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584
- Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:
- Morsli, S., Henriques, C.M., Ellis, P.S., Mortiboys, H., Baxendale, S., Loynes, C.A., Renshaw, S.A., Bellantuono, I. (2023) A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell. 22(6):e13835
- Zapilko, V., Moisio, S., Parikka, M., Heinäniemi, M., Lohi, O. (2023) Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers. 15(24):
- Zhang, Y., Peng, X., Xue, M., Liu, J., Shang, G., Jiang, M., Chen, D., Liu, B., Wang, Y., Jia, X., Xu, J., Zhang, F., Hu, Y. (2023) SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway. Biogerontology. 24(5):813-827
- Haraoka, Y., Akieda, Y., Nagai, Y., Mogi, C., Ishitani, T. (2022) Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Nature communications. 13:1417
- Tian, Y., Wang, W., Lautrup, S., Zhao, H., Li, X., Law, P.W.N., Dinh, N.D., Fang, E.F., Cheung, H.H., Chan, W.Y. (2022) WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nature communications. 13:5456
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Cui, X., Du, C., Wan, S., Wu, D., Yan, L., Zhang, J., Li, J., Li, H., Yang, Z., Zhang, H., Zhang, J., Mu, H., Zhang, F., Peng, X., Liu, M., Hu, Y. (2021) Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21cip1 expression. Biochimica et biophysica acta. Molecular basis of disease. 1867(11):166233
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