Gene
golga2
- ID
- ZDB-GENE-081030-1
- Name
- golgin A2
- Symbol
- golga2 Nomenclature History
- Previous Names
-
- cis-Golgi matrix protein GM130
- drgm130
- si:dkey-246l19.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within brain development; skeletal muscle tissue development; and thigmotaxis. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment membrane; and microtubule cytoskeleton. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. Is expressed in otic vesicle. Orthologous to several human genes including GOLGA2 (golgin A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shamseldin et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa20328 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-golga2 | N/A | Shamseldin et al., 2016 |
MO2-golga2 | N/A | Shamseldin et al., 2016 |
1 - 2 of 2
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Developmental delay with hypotonia, myopathy, and brain abnormalities | 620240 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Golgin subfamily A | Golgin subfamily A, conserved domain | Golgin subfamily A member 2, C-terminal binding motif |
---|---|---|---|---|---|
UniProtKB:A0A8M3B239 | InterPro | 1056 | |||
UniProtKB:A0A8M3ARU7 | InterPro | 1027 | |||
UniProtKB:A0A8M2BFH4 | InterPro | 1024 | |||
UniProtKB:A0A8M3AS19 | InterPro | 1059 | |||
UniProtKB:A1IH00 | InterPro | 1028 |
1 - 5 of 8 Show all
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
golga2-201
(1)
|
Ensembl | 3,517 nt | ||
mRNA |
golga2-203
(1)
|
Ensembl | 250 nt | ||
mRNA |
golga2-204
(1)
|
Ensembl | 540 nt | ||
mRNA |
golga2-205
(1)
|
Ensembl | 513 nt | ||
ncRNA |
golga2-002
(1)
|
Ensembl | 612 nt |
1 - 5 of 6 Show all
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-golga2 | monoclonal | IgG1 , k | Mouse |
|
BD Biosciences
|
17 |
1 - 1 of 1
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-89I7 | ZFIN Curated Data | |
Contained in | BAC | DKEY-246L19 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001127334 (1) | 3087 nt | ||
Genomic | GenBank:CU138550 (2) | 138123 nt | ||
Polypeptide | UniProtKB:A0A8M3AS19 (1) | 1059 aa |
- Bragato, C., Pistocchi, A., Bellipanni, G., Confalonieri, S., Balciunie, J., Monastra, F.M., Carra, S., Vitale, G., Mantecca, P., Cotelli, F., Gaudenzi, G. (2023) Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue. Journal of neuroscience research. 101(8):1345-1359
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Bergen, D.J.M., Stevenson, N.L., Skinner, R.E.H., Stephens, D.J., Hammond, C.L. (2017) The Golgi matrix protein giantin is required for normal cilia function in zebrafish. Biology Open. 6(8):1180-1189
- Kantarci, H., Gerberding, A., Riley, B.B. (2016) Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle. Proceedings of the National Academy of Sciences of the United States of America. 113(44):E6840-E6848
- Shamseldin, H.E., Bennett, A.H., Alfadhel, M., Gupta, V., Alkuraya, F.S. (2016) GOLGA2, encoding a master regulator of golgi apparatus, is mutated in a patient with a neuromuscular disorder. Human genetics. 135(2):245-51
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Coyle, R.C., Latimer, A., and Jessen, J.R. (2008) Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: Evidence for an interaction with non-canonical Wnt signaling. Experimental cell research. 314(10):2150-2162
1 - 7 of 7
Show