Gene
cabp2b
- ID
- ZDB-GENE-081028-55
- Name
- calcium binding protein 2b
- Symbol
- cabp2b Nomenclature History
- Previous Names
-
- si:ch211-113d11.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel regulator activity. Predicted to be active in cytoplasm. Is expressed in inner ear; neuromast; and utricle. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 93. Orthologous to human CABP2 (calcium binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-cabp2b | Lin et al., 2025 | |
CRISPR2-cabp2b | Lin et al., 2025 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal recessive nonsyndromic deafness 93 | Alliance | Deafness, autosomal recessive 93 | 614899 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Calcium binding protein 1/2/4/5 | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
---|---|---|---|---|---|---|
UniProtKB:A0A8M9PZY4 | InterPro | 251 | ||||
UniProtKB:A0A8M9QBP2 | InterPro | 228 | ||||
UniProtKB:A0A2R8QK74 | InterPro | 163 | ||||
UniProtKB:A0A8M9QL43 | InterPro | 262 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cabp2b-201
(1)
|
Ensembl | 648 nt | ||
mRNA |
cabp2b-202
(1)
|
Ensembl | 889 nt | ||
mRNA |
cabp2b-203
(1)
|
Ensembl | 917 nt | ||
mRNA |
cabp2b-205
(1)
|
Ensembl | 2,724 nt | ||
mRNA |
cabp2b-206
(1)
|
Ensembl | 1,460 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-113D11 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_005169623 (1) | 966 nt | ||
Genomic | GenBank:BX005077 (1) | 127560 nt | ||
Polypeptide | UniProtKB:A0A8M9QL43 (1) | 262 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | CABP2 | 11 | Amino acid sequence comparison (1) |
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Madera, D., Alonso-Gómez, A., Delgado, M.J., Valenciano, A.I., Alonso-Gómez, Á.L. (2023) Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. International Journal of Molecular Sciences. 25(1):
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Barta, C.L., Liu, H., Chen, L., Giffen, K.P., Li, Y., Kramer, K.L., Beisel, K.W., He, D.Z. (2018) RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells. Scientific data. 5:180005
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Di Donato, V., Auer, T.O., Duroure, K., and Del Bene, F. (2013) Characterization of the calcium binding protein family in zebrafish. PLoS One. 8(1):e53299
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