PUBLICATION

Characterization of the calcium binding protein family in zebrafish

Authors
Di Donato, V., Auer, T.O., Duroure, K., and Del Bene, F.
ID
ZDB-PUB-130131-24
Date
2013
Source
PLoS One   8(1): e53299 (Journal)
Registered Authors
Del Bene, Filippo
Keywords
Zebrafish, Retina, Notochords, Embryos, Complementary DNA, Inner ear, Protein domains, Thalamus
MeSH Terms
  • Gene Expression Regulation, Developmental
  • Calcium-Binding Proteins/genetics
  • Calcium-Binding Proteins/metabolism*
  • Phylogeny
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Mice
  • Embryo, Nonmammalian/metabolism
  • Multigene Family*
  • Animals
(all 13)
PubMed
23341937 Full text @ PLoS One
Abstract

Calcium Binding Proteins (CaBPs), part of the vast family of EF-Hand-domain containing proteins, modulate intracellular calcium levels. They thereby contribute to a broad spectrum of biological processes – amongst others cell migration, gene expression and neural activity. In this study we identified twelve members of this protein family in zebrafish including one gene (cabp4b) currently not present in the zebrafish genome assembly. To gain insight into their biological functions, we carried out a detailed analysis of the expression patterns of these genes during zebrafish late embryonic and early larval development. We detected specific transcription for most of them in different neuronal cell populations including the neuroretina, the inner ear and the notochord. Our data supports potential roles for CaBPs during neuronal development and function and provides a starting point for genetic studies to examine CaBPs' function in these tissues and organs.

Genes / Markers
Figures
Figure Gallery (10 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
jh1TgTransgenic Insertion
    nns5TgTransgenic Insertion
      s356tTgTransgenic Insertion
        1 - 3 of 3
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        Human Disease / Model
        No data available
        Sequence Targeting Reagents
        No data available
        Fish
        1 - 4 of 4
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        Antibodies
        No data available
        Orthology
        Gene Orthology
        cabp2a
        cabp2b
        cabp4
        caln1
        1 - 4 of 4
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        Engineered Foreign Genes
        Marker Marker Type Name
        EGFPEFGEGFP
        GFPEFGGFP
        1 - 2 of 2
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        Mapping
        No data available