Gene
lepa
- ID
- ZDB-GENE-081001-1
- Name
- leptin a
- Symbol
- lepa Nomenclature History
- Previous Names
-
- lep
- ob (1)
- si:dkey-98o11.2
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity and leptin receptor binding activity. Acts upstream of or within camera-type eye development; inner ear development; and nervous system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cy50 | Allele with one deletion | Exon 2 | Unknown | TALEN | |
| nz301 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| umo37 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| vu621 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| vu622 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lepa | (2) | |
| CRISPR2-lepa | (2) | |
| CRISPR3-lepa | (2) | |
| CRISPR4-lepa | Hu et al., 2022 | |
| CRISPR5-lepa | Hu et al., 2022 | |
| CRISPR6-lepa | (2) | |
| CRISPR7-lepa | Mazzaferro et al., 2025 | |
| MO1-lepa | N/A | Yu et al., 2012 |
| MO2-lepa | N/A | (3) |
| MO3-lepa | N/A | Liu et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital leptin deficiency | Alliance | Obesity, morbid, due to leptin deficiency | 614962 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Leptin |
|---|---|---|---|---|
| UniProtKB:Q0D250 | InterPro | 166 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-98O11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128576 (1) | 501 nt | ||
| Genomic | GenBank:BX927136 (2) | 93818 nt | ||
| Polypeptide | UniProtKB:Q0D250 (1) | 166 aa |
- Chen, Y., Zheng, K., Leng, Y., Zhang, Z., Li, X., Li, X., Ou, H., Wen, M., Qiu, F., Yu, H. (2025) Alleviating effect of Lactobacillus fermentum E15 on hyperlipidemia and hepatic lipid metabolism in zebrafish fed by a high-fat diet through the production of short-chain fatty acids. Frontiers in nutrition. 12:15229821522982
- Mazzaferro, E., Mujica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R.J., Vienberg, S.G., Larsson, A., Allalou, A., den Hoed, M. (2025) Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. Scientific Reports. 15:54085408
- Hui, J.C.M., Du, P., Webb, S.E., Liu, J.Y.H., Ngan, M.P., Lu, Z., Ng, H.S.H., Yang, L., Khalid, A., Liu, L., Li, Z., Deng, Y., Cui, D., Rudd, J.A. (2024) Imaging analytical technique to assess gastrointestinal motility in vivo using zebrafish larvae with diabetes mellitus-like traits. PLoS One. 19:e0314515e0314515
- Kaplan, G., Beler, M., Ünal, I., Karagöz, A., Eğilmezer, G., Üstündağ, Ü.V., Cansız, D., Alturfan, A.A., Emekli-Alturfan, E. (2024) Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos. Toxicology and industrial health. 40(5):232-243
- Rajeswari, J.J., Faught, E., Santos, H., Vijayan, M.M. (2024) Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin. Journal of Cellular Physiology. 239(12):e31428
- Wu, J., Zhuang, W., Lu, K., Zhang, L., Wang, Y., Chai, F., Liang, X.F. (2024) Study on the Function of Leptin Nutrient Acquisition and Energy Metabolism of Zebrafish (Danio rerio). International Journal of Molecular Sciences. 25(21):
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Liu, Y., Zhu, D., Liu, J., Sun, X., Gao, F., Duan, H., Dong, L., Wang, X., Wu, C. (2023) Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish. Frontiers in nutrition. 10:10877031087703
- Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973
- Wei, Z., Bagivalu Lakshminarasimha, A., Cone, R., Michel, M. (2023) Loss of Agrp1 in zebrafish: Effects on the growth and reproductive axis. General and comparative endocrinology. 336:114243
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