Gene
sema4c
- ID
- ZDB-GENE-080303-16
- Name
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
- Symbol
- sema4c Nomenclature History
- Previous Names
-
- sc:d411 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Acts upstream of or within motor neuron axon guidance. Predicted to be located in membrane. Predicted to be active in plasma membrane and synaptic vesicle membrane. Is expressed in several structures, including brain; cardiovascular system; lens placode; olfactory epithelium; and solid lens vesicle. Orthologous to human SEMA4C (semaphorin 4C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d411 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sheng et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12361 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20361 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20362 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25291 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30613 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33553 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33554 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sema4c | Sheng et al., 2022 | |
| MO1-sema4c | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Plexin repeat | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4JYS4 | InterPro | 863 | |||||||||
| UniProtKB:F1QF70 | InterPro | 863 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema4c-201
(1)
|
Ensembl | 3,297 nt | ||
| mRNA |
sema4c-202
(1)
|
Ensembl | 3,075 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-sema4c | monoclonal | Mouse |
|
1 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244O22 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d411 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128246 (1) | 2592 nt | ||
| Genomic | GenBank:CR392037 (1) | 140415 nt | ||
| Polypeptide | UniProtKB:A4JYS4 (1) | 863 aa |
- Sheng, J., Gong, J., Shi, Y., Wang, X., Liu, D. (2022) MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development. Open Biology. 12:210315
- Sheng, J., Jiang, B., Shi, R., Shi, L., Liu, D. (2022) Sema4C Is Required for Vascular and Primary Motor Neuronal Patterning in Zebrafish. Cells. 11(16)
- Zheng, Y.Q., Suo, G.H., Liu, D., Li, H.Y., Wu, Y.J., Ni, H. (2022) Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience. 15:848257
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Staudt, N., Müller-Sienerth, N., Fane-Dremucheva, A., Yusaf, S.P., Millrine, D., Wright, G.J. (2015) A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Biochemical and Biophysical Research Communications. 456(1):527-33
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