Gene
lepr
- ID
- ZDB-GENE-080104-1
- Name
- leptin receptor
- Symbol
- lepr Nomenclature History
- Previous Names
-
- obr (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in leptin-mediated signaling pathway and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including oocyte maturation; ovulation; and type B pancreatic cell development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb251 | Allele with one delins | Exon 8 | Unknown | CRISPR | |
| ihb252 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| la025495Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nz303 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa323 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1508 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa5372 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12953 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38556 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| umo39 | Allele with one delins | Unknown | Frameshift, Premature Stop | CRISPR |
1 - 10 of 14
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lepr | Zebrafish Nomenclature Committee | |
| CRISPR2-lepr | (2) | |
| CRISPR3-lepr | (2) | |
| CRISPR4-lepr | (5) | |
| CRISPR5-lepr | (3) | |
| CRISPR6-lepr | Del Vecchio et al., 2021 | |
| CRISPR7-lepr | Hu et al., 2022 | |
| MO1-lepr | N/A | (2) |
| MO2-lepr | N/A | Zhao et al., 2014 |
1 - 9 of 9
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Obesity, morbid, due to leptin receptor deficiency | 614963 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR010457 | Immunoglobulin C2-set-like, ligand-binding |
| Domain | IPR041182 | Leptin receptor, immunoglobulin-like domain |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin C2-set-like, ligand-binding | Immunoglobulin-like fold | Leptin receptor, immunoglobulin-like domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P6L4 | InterPro | 1065 | |||||
| UniProtKB:A0AB32TVW1 | InterPro | 1075 |
1 - 2 of 2
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-lepr | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 | |
| Ab1-lepr | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
1 - 2 of 2
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(lepr:lepr-mCherry) |
|
|
| 1 | (2) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157E20 | ||
| Contained in | BAC | DKEY-1K24 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309403 (1) | 3513 nt | ||
| Genomic | GenBank:BX936440 (2) | 197744 nt | ||
| Polypeptide | UniProtKB:A0AB32TVW1 (1) | 1075 aa |
- Mazzaferro, E., Mujica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R.J., Vienberg, S.G., Larsson, A., Allalou, A., den Hoed, M. (2025) Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. Scientific Reports. 15:54085408
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Hu, Z., Ai, N., Chen, W., Wong, Q.W., Ge, W. (2022) Leptin and Its Signaling Are Not Involved in Zebrafish Puberty Onset. Biology of reproduction. 106(5):928-942
- Kamstra, K., Rizwan, M.Z., Grattan, D.R., Horsfield, J.A., Tups, A. (2022) Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22207
- Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
- Smeeton, J., Natarajan, N., Anderson, T., Tseng, K.C., Fabian, P., Crump, J.G. (2022) Regeneration of Jaw Joint Cartilage in Adult Zebrafish. Frontiers in cell and developmental biology. 9:777787
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Bagivalu Lakshminarasimha, A., Page McCaw, P., Möckel, D., Gremse, F., Michel, M. (2021) Leptin system loss of function in the absence of obesity in zebrafish. The Journal of endocrinology. 251(1):41-52
- Del Vecchio, G., Murashita, K., Verri, T., Gomes, A.S., Rønnestad, I. (2021) Leptin receptor-deficient (knockout) zebrafish: effects on nutrient acquisition. General and comparative endocrinology. 310:113832
1 - 10 of 54
Show