Gene

lepr

ID
ZDB-GENE-080104-1
Name
leptin receptor
Symbol
lepr Nomenclature History
Previous Names
  • obr (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in leptin-mediated signaling pathway and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including oocyte maturation; ovulation; and type B pancreatic cell development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb251Allele with one delinsExon 8UnknownCRISPR
ihb252Allele with one deletionExon 8UnknownCRISPR
la025495TgTransgenic insertionUnknownUnknownDNA
nz303Allele with one deletionUnknownUnknownCRISPR
sa323Allele with one point mutationUnknownPremature StopENU
sa1508Allele with one point mutationUnknownPremature StopENU
sa5372Allele with one point mutationUnknownPremature StopENU
sa12953Allele with one point mutationUnknownPremature StopENU
sa38556Allele with one point mutationUnknownPremature StopENU
umo39Allele with one delinsUnknownFrameshift, Premature StopCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With lepr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Obesity, morbid, due to leptin receptor deficiency 614963
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Associated With lepr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003961 Fibronectin type III
Domain IPR010457 Immunoglobulin C2-set-like, ligand-binding
Domain IPR041182 Leptin receptor, immunoglobulin-like domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
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Domain Details Per Protein
Protein Additional Resources Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin C2-set-like, ligand-binding Immunoglobulin-like fold Leptin receptor, immunoglobulin-like domain
UniProtKB:A0A8M1P6L4 InterPro 1065
UniProtKB:A0AB32TVW1 InterPro 1075
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 6
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA lepr-201 (1) Ensembl 5,772 nt
mRNA lepr-202 (1) Ensembl 3,267 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-lepr polyclonal IgG Goat
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
2
Ab1-lepr polyclonal IgG Goat
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
2
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(lepr:lepr-mCherry)
  • lepr
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-157E20
Contained inBACDKEY-1K24
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanLEPR1
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseLepr4
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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