Gene
tjp1b
- ID
- ZDB-GENE-070925-1
- Name
- tight junction protein 1b
- Symbol
- tjp1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within gap junction assembly; protein localization to synapse; and synapse assembly. Predicted to be located in gap junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including axial mesoderm; cardiovascular system; epidermis; nervous system; and pleuroperitoneal region. Orthologous to human TJP1 (tight junction protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1370 | Allele with one delins | Unknown | Unknown | CRISPR | |
| b1406Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| b1435 | Allele with one point mutation | Unknown | Unknown | not specified | |
| e122Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| fh448 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| fh449 | Allele with one delins | Unknown | Unknown | CRISPR | |
| fh451 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa13104 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15532 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44339 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tjp1b | (7) | |
| CRISPR2-tjp1b | (4) | |
| CRISPR3-tjp1b | Lasseigne et al., 2021 | |
| CRISPR4-tjp1b | Miles et al., 2024 | |
| CRISPR5-tjp1b | Miles et al., 2024 | |
| MO1-tjp1b | N/A | Fadeev et al., 2015 |
| MO2-tjp1b | N/A | Schwayer et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CARD domain | Death-like domain superfamily | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Tight junction protein ZO | Tight junction protein ZO-1 | ZO-1, SH3 domain | ZU5 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PZ36 | InterPro | 2040 | |||||||||||||
| UniProtKB:A0A8M9PHG3 | InterPro | 2030 | |||||||||||||
| UniProtKB:A0A8M9PZ42 | InterPro | 2028 | |||||||||||||
| UniProtKB:A0A8M9P6X7 | InterPro | 2031 | |||||||||||||
| UniProtKB:A0A8M6YYG5 | InterPro | 2015 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tjp1 | monoclonal | IgG1 , k | Mouse |
|
Life Technologies (Invitrogen)
Thermo Fisher Scientific (Lab Vision) |
244 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(actb2:mNeonGreen-tjp1b) |
|
| 1 | Schwayer et al., 2019 | |
| Tg(actb1:myl12.1-mCherry,actb2:mNeonGreen-tjp1b) |
|
| 1 | Schwayer et al., 2019 | |
| Tg(actb2:mNeonGreen-tjp1b) |
|
| 2 | Schwayer et al., 2019 | |
| Tg(actb2:mNeonGreen-tjp1b,actb1:utrn-mCherry) |
|
| 1 | Schwayer et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-339E3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-33L14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021470723 (1) | 7845 nt | ||
| Genomic | GenBank:CR847962 (2) | 209896 nt | ||
| Polypeptide | UniProtKB:A0A8M9PHF8 (1) | 2043 aa |
- Miles, K.D., Barker, C.M., Russell, K.P., Appel, B.H., Doll, C.A. (2024) Electrical synapses mediate embryonic hyperactivity in a zebrafish model of Fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(31):
- Liao, X., Lan, Y., Wang, W., Zhang, J., Shao, R., Yin, Z., Gudmundsson, G.H., Bergman, P., Mai, K., Ai, Q., Wan, M. (2023) Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogens. Gut microbes. 15:21875752187575
- Pellegrini, E., Fernezelian, D., Malleret, C., Gueguen, M.M., Patche-Firmin, J., Rastegar, S., Meilhac, O., Diotel, N. (2023) Estrogenic regulation of claudin 5 and tight junction protein 1 gene expression in zebrafish: A role on blood-brain barrier?. The Journal of comparative neurology. 531(17):1828-1845
- Michel, J.C., Lasseigne, A.M., Marsh, A.J., Miller, A.C. (2022) The disconnect2 mutation disrupts the tjp1b gene that is required for electrical synapse formation. microPublication. Biology. 2022:
- Lasseigne, A.M., Echeverry, F.A., Ijaz, S., Michel, J.C., Martin, E.A., Marsh, A.J., Trujillo, E., Marsden, K.C., Pereda, A.E., Miller, A.C. (2021) Electrical synaptic transmission requires a postsynaptic scaffolding protein. eLIFE. 10:
- Zhang, F.L., Yang, Y.L., Zhang, Z., Yao, Y.Y., Xia, R., Gao, C.C., Du, D.D., Hu, J., Ran, C., Liu, Z., Zhou, Z.G. (2021) Surface-Displayed Amuc_1100 From Akkermansia muciniphila on Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish. Frontiers in nutrition. 8:726108
- Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A.V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S.C., Hsiai, T.K., Lin, X., Xu, X. (2020) Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Science advances. 6:eaay2939
- Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330
- Espenschied, S.T., Cronan, M.R., Matty, M.A., Mueller, O., Redinbo, M.R., Tobin, D.M., Rawls, J.F. (2019) Epithelial delamination is protective during pharmaceutical-induced enteropathy. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16961-16970
- Rödel, C.J., Otten, C., Donat, S., Lourenco, M., Fischer, D., Kuropka, B., Paolini, A., Freund, C., Abdelilah-Seyfried, S. (2019) Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Circulation research. 125(10):e43-e54
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