Gene

atr

ID
ZDB-GENE-070912-458
Name
ATR checkpoint kinase
Symbol
atr Nomenclature History
Previous Names
  • si:dkey-231j24.1
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including determination of left/right symmetry; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of heart looping. Predicted to be located in nuclear envelope. Predicted to be active in chromosome and nucleus. Is expressed in hindbrain neural rod; midbrain neural rod; optic vesicle; somite; and tail bud. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Stiff et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la023474TgTransgenic insertionUnknownUnknownDNA
sa6829Allele with one point mutationUnknownPremature StopENU
sa14005Allele with one point mutationUnknownPremature StopENU
sa14645Allele with one point mutationUnknownSplice SiteENU
sa15319Allele with one point mutationUnknownSplice SiteENU
sa19711Allele with one point mutationUnknownPremature StopENU
sa32869Allele with one point mutationUnknownSplice SiteENU
sa32870Allele with one point mutationUnknownPremature StopENU
sa38321Allele with one point mutationUnknownSplice SiteENU
sa39800Allele with one point mutationUnknownSplice SiteENU
1 - 10 of 10
Show
Sequence Targeting Reagents
1 - 4 of 4
Show
Human Disease
Associated With atr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Seckel syndrome 1 Alliance Seckel syndrome 1 210600
?Cutaneous telangiectasia and cancer syndrome, familial 614564
1 - 2 of 2
Associated With atr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003151 PIK-related kinase, FAT
Domain IPR003152 FATC domain
Domain IPR012993 UME domain
1 - 5 of 12 Show all
Domain Details Per Protein
Protein Additional Resources Length Armadillo-like helical Armadillo-type fold DNA Damage Response and Repair Kinase FATC domain Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase PIK-related kinase, FAT Protein kinase-like domain superfamily Tetratricopeptide-like helical domain superfamily UME domain
UniProtKB:A0A8M9P8M6 InterPro 2077
UniProtKB:A0A8N7TEF8 InterPro 2633
1 - 2 of 2
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA atr-202 (1) Ensembl 8,277 nt
ncRNA atr-002 (1) Ensembl 770 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-atr polyclonal Rabbit
  • WB
Abcam plc
1
1 - 1 of 1
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-231J24ZFIN Curated Data
Contained inBACDKEYP-13A3ZFIN Curated Data
1 - 2 of 2
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanATR3
Amino acid sequence comparison (1)
Citations
1 - 10 of 19
Show