Gene
atr
- ID
- ZDB-GENE-070912-458
- Name
- ATR checkpoint kinase
- Symbol
- atr Nomenclature History
- Previous Names
-
- si:dkey-231j24.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including determination of left/right symmetry; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of heart looping. Predicted to be located in nuclear envelope. Predicted to be active in chromosome and nucleus. Is expressed in hindbrain neural rod; midbrain neural rod; optic vesicle; somite; and tail bud. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Stiff et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la023474Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa6829 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa14005 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa14645 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa15319 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa19711 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32869 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa32870 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38321 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa39800 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-atr | Shin et al., 2021 | |
MO1-atr | N/A | (4) |
MO2-atr | N/A | Stiff et al., 2016 |
TALEN1-atr | Thomas et al., 2014 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Seckel syndrome 1 | Alliance | Seckel syndrome 1 | 210600 |
?Cutaneous telangiectasia and cancer syndrome, familial | 614564 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | DNA Damage Response and Repair Kinase | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Tetratricopeptide-like helical domain superfamily | UME domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9P8M6 | InterPro | 2077 | ||||||||||||
UniProtKB:A0A8N7TEF8 | InterPro | 2633 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-231J24 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-13A3 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_021467053 (1) | |||
Genomic | GenBank:CR377211 (1) | 186342 nt | ||
Polypeptide | UniProtKB:A0A8N7TEF8 (1) | 2633 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | ATR | 3 | Amino acid sequence comparison (1) |
- Boos, A., Gahr, B.M., Park, D.D., Braun, V., Bühler, A., Rottbauer, W., Just, S. (2023) Hdac1-deficiency affects the cell cycle axis Cdc25-Cdk1 causing impaired G2/M phase progression and reduced cardiomyocyte proliferation in zebrafish. Biochemical and Biophysical Research Communications. 665:9810698-106
- Babu, S., Takeuchi, Y., Masai, I. (2022) Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. eLIFE. 11
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Li, X., Song, G., Zhao, Y., Ren, J., Li, Q., Cui, Z. (2021) Functions of SMC2 in the Development of Zebrafish Liver. Biomedicines. 9(9):
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Honjo, Y., Ichinohe, T. (2019) Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Cell biology international. 43(5):516-527
- Komoike, Y., Matsuoka, M. (2018) In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish. Journal of hazardous materials. 365:430-439
- Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572
- Stiff, T., Casar Tena, T., O'Driscoll, M., Jeggo, P.A., Philipp, M. (2016) ATR promotes cilia signalling; links to developmental impacts. Human molecular genetics. 25(8):1574-87
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