Gene
myhz1.2
- ID
- ZDB-GENE-070705-73
- Name
- myosin, heavy polypeptide 1.2, skeletal muscle
- Symbol
- myhz1.2 Nomenclature History
- Previous Names
-
- fmyhc1.2 (1)
- ns:zf-e523
- si:ch211-158m24.8
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in system development. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in cephalic musculature and trunk. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); disease of cellular proliferation; and distal arthrogryposis (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa10023 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11919 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa15463 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16809 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa25302 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31460 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33638 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33639 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-myha,myhc4,myhz1.1,myhz1.2,myhz1.3,myhz2 | Lin et al., 2025 | |
MO1-myhz1.2 | N/A | Nord et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001609 | Myosin head, motor domain-like |
Domain | IPR002928 | Myosin tail |
Domain | IPR004009 | Myosin, N-terminal, SH3-like |
Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
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Domain Details Per Protein
Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QEC8 | InterPro | 1937 | |||||||
UniProtKB:A0A2R8Q2N5 | InterPro | 1935 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
myhz1.2-201
(1)
|
Ensembl | 6,016 nt | ||
mRNA |
myhz1.2-202
(1)
|
Ensembl | 5,975 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(myhz1.2:EGFP) |
|
| 1 | Asaduzzaman et al., 2016 | |
Tg(myhz1.2:GFP) |
|
| 1 | (3) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-158M24 | ZFIN Curated Data | |
Encodes | EST | zf-e523 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001161446 (1) | 5975 nt | ||
Genomic | GenBank:BX510649 (1) | 189844 nt | ||
Polypeptide | UniProtKB:A0A8M9QEC8 (1) | 1937 aa |
No data available
- Liu, G., Ito, T., Kijima, Y., Yoshitake, K., Asakawa, S., Watabe, S., Kinoshita, S. (2022) Zebrafish Danio rerio myotomal muscle structure and growth from a spatial transcriptomics perspective. Genomics. 114(5):110477
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652
- Xu, Q.H., Guan, P., Zhang, T., Lu, C., Li, G., Liu, J.X. (2018) Silver nanoparticles impair zebrafish skeletal and cardiac myofibrillogenesis and sarcomere formation. Aquatic toxicology (Amsterdam, Netherlands). 200:102-113
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lu, C., Wu, J., Xiong, S., Zhang, X., Zhang, J., Mei, J. (2017) MicroRNA-203a regulates fast muscle differentiation by targeting dmrt2a in zebrafish embryos. Gene. 625:49-54
- Wen, Y., Ushio, H. (2017) Ferulic Acid Promotes Hypertrophic Growth of Fast Skeletal Muscle in Zebrafish Model. Nutrients. 9(10)
- Asaduzzaman, M., Shakur Ahammad, A.K., Asakawa, S., Kinoshita, S., Watabe, S. (2016) 5′-flanking sequences of zebrafish fast myosin heavy chain genes regulate unique expression in the anterior, medial subsection and posterior tail somites of the skeletal muscle. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 191:1-12
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nord, H., Burguiere, A.C., Muck, J., Nord, C., Ahlgren, U., and von Hofsten, J. (2014) Differential regulation of myosin heavy chains defines new muscle domains in zebrafish. Molecular biology of the cell. 25(8):1384-95
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