Gene
panx1b
- ID
- ZDB-GENE-070705-192
- Name
- pannexin 1b
- Symbol
- panx1b Nomenclature History
- Previous Names
-
- si:ch211-69i14.7
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables voltage-gated channel activity and wide pore channel activity. Acts upstream of or within detection of light stimulus involved in visual perception and swimming behavior. Located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including central nervous system; eye; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human PANX1 (pannexin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Oocyte/zygote/embryo maturation arrest 7 | 618550 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Innexin | Pannexin |
---|---|---|---|---|
UniProtKB:A0A8M9Q3P2 | InterPro | 259 | ||
UniProtKB:F1QSR7 | InterPro | 422 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
panx1b-201
(1)
|
Ensembl | 2,881 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab2-panx1b | polyclonal | IgG | Rabbit |
|
1 | ||
Ab1-panx1b | IgY | Chicken |
|
1 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-69I14 | ZFIN Curated Data | |
Contained in | BAC | CH211-139A5 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001100030 (1) | 2906 nt | ||
Genomic | GenBank:AL935065 | 167740 nt | ||
Polypeptide | UniProtKB:F1QSR7 (1) | 422 aa |
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Safarian, N., Houshangi-Tabrizi, S., Zoidl, C., Zoidl, G.R. (2021) Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish. International Journal of Molecular Sciences. 22(21):
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- de Marchi, F.O., Cruz, F.F., Menezes, F.P., Kist, L.W., Bogo, M.R., Morrone, F.B. (2019) P2X7R and PANX-1 channel relevance in a zebrafish larvae copper-induced inflammation model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 223:62-70
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Cenedese, V., de Graaff, W., Csikós, T., Poovayya, M., Zoidl, G., Kamermans, M. (2017) Pannexin 1 Is Critically Involved in Feedback from Horizontal Cells to Cones. Frontiers in molecular neuroscience. 10:403
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Kurtenbach, S., Prochnow, N., Kurtenbach, S., Klooster, J., Zoidl, C., Dermietzel, R., Kamermans, M., and Zoidl, G. (2013) Pannexin1 channel proteins in the zebrafish retina have shared and unique properties. PLoS One. 8(10):e77722
- Bond, S.R., Wang, N., Leybaert, L., and Naus, C.C. (2012) Pannexin 1 Ohnologs in the Teleost Lineage. The Journal of membrane biology. 245(8):483-493
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