Gene
ahctf1
- ID
- ZDB-GENE-070521-2
- Name
- AT hook containing transcription factor 1
- Symbol
- ahctf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including hepatocyte proliferation; nuclear pore complex assembly; and regulation of hepatocyte apoptotic process. Predicted to be located in nucleus. Is expressed in brain; digestive system; head; immature eye; and pectoral fin. Orthologous to human AHCTF1 (AT-hook containing transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| s871 | Allele with one point mutation | Unknown | Unknown | not specified | |
| sa664 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9115 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23014 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28817 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32129 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ti262c | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tsu13i7d | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| tsu14i1d | Allele with one delins | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ahctf1 | (2) | |
| MO1-ahctf1 | N/A | Davuluri et al., 2008 |
| MO2-ahctf1 | N/A | Davuluri et al., 2008 |
| MO3-ahctf1 | N/A | Davuluri et al., 2008 |
| MO4-ahctf1 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ELYS, beta-propeller domain | ELYS-like domain | ELYS/MEL-28 Nuclear Assembly Factor |
|---|---|---|---|---|---|
| UniProtKB:A0A8N7T6T7 | InterPro | 2527 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ahctf1-201
(1)
|
Ensembl | 8,109 nt | ||
| mRNA |
ahctf1-202
(1)
|
Ensembl | 9,380 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-3I24 | Davuluri et al., 2008 | |
| Contained in | BAC | RP71-84D9 | Davuluri et al., 2008 | |
| Contains | SNP | rs3728847 | ZFIN Curated Data | |
| Encodes | EST | fa02e01 | ||
| Encodes | EST | wz11290 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_692635 (1) | 8511 nt | ||
| Genomic | GenBank:AL954168 | 205011 nt | ||
| Polypeptide | UniProtKB:A0A8N7T6T7 (1) | 2527 aa |
- Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:
- Shen, W., Gong, B., Xing, C., Zhang, L., Sun, J., Chen, Y., Yang, C., Yan, L., Chen, L., Yao, L., Li, G., Deng, H., Wu, X., Meng, A. (2022) Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell. 185(26):4954-4970.e20
- Cerveny, K.L., Bronstein, H., Hagen, O., Lamb, D.B., Martin, G., Tower, I., Van Duzer, A., Welch, E., Varga, M. (2021) Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. microPublication. Biology. 2021:
- Kansara, K., Kumar, A., Karakoti, A.S. (2019) Combination of humic acid and clay reduce the ecotoxic effect of TiO2 NPs: A combined physico-chemical and genetic study using zebrafish embryo. The Science of the total environment. 698:134133
- Kansara, K., Paruthi, A., Misra, S.K., Karakoti, A.S., Kumar, A. (2019) Montmorillonite clay and humic acid modulate the behavior of copper oxide nanoparticles in aqueous environment and induces developmental defects in zebrafish embryo. Environmental pollution (Barking, Essex : 1987). 255:113313
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Cerveny, K.L., Cavodeassi, F., Turner, K.J., de Jong-Curtain, T.A., Heath, J.K., and Wilson, S.W. (2010) The zebrafish flotte lotte mutant reveals that the local retinal environment promotes the differentiation of proliferating precursors emerging from their stem cell niche. Development (Cambridge, England). 137(13):2107-2115
- de Jong-Curtain, T.A., Parslow, A.C., Trotter, A.J., Hall, N.E., Verkade, H., Tabone, T., Christie, E.L., Crowhurst, M.O., Layton, J.E., Shepherd, I.T., Nixon, S.J., Parton, R.G., Zon, L.I., Stainier, D.Y., Lieschke, G.J., and Heath, J.K. (2009) Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. Gastroenterology. 136(3):902-911
- Davuluri, G., Gong, W., Yusuff, S., Lorent, K., Muthumani, M., Dolan, A.C., and Pack, M. (2008) Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genetics. 4(10):e1000240
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