Gene
ca15a
- ID
- ZDB-GENE-070424-7
- Name
- carbonic anhydrase XVa
- Symbol
- ca15a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable carbonate dehydratase activity. Acts upstream of or within regulation of pH and sodium ion import across plasma membrane. Located in external side of plasma membrane. Is expressed in several structures, including gill; hair cell; ionocyte; pleuroperitoneal region; and yolk.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ca15a | N/A | Lin et al., 2008 |
| MO2-ca15a | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018338 | Carbonic anhydrase, alpha-class, conserved site |
| Domain | IPR001148 | Alpha carbonic anhydrase domain |
| Family | IPR023561 | Carbonic anhydrase, alpha-class |
| Family | IPR041874 | Carbonic anhydrase, CA4/CA15 |
| Homologous_superfamily | IPR036398 | Alpha carbonic anhydrase domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha carbonic anhydrase domain | Alpha carbonic anhydrase domain superfamily | Carbonic anhydrase, alpha-class | Carbonic anhydrase, alpha-class, conserved site | Carbonic anhydrase, CA4/CA15 |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q816 | InterPro | 324 | |||||
| UniProtKB:A2VD39 | InterPro | 324 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173D10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158584 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001081689 (1) | 1419 nt | ||
| Genomic | GenBank:CU571308 (1) | 141745 nt | ||
| Polypeptide | UniProtKB:A2VD39 (1) | 324 aa |
No data available
- Hansen, C.L., Chamberlain, T.J., Trevena, R.L., Kurek, J.E., Pelegri, F. (2021) Conserved germ plasm characteristics across the Danio and Devario lineages. Genesis (New York, N.Y. : 2000). 59(10):e23452
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Matsumoto, H., Fujiwara, S., Miyagi, H., Nakamura, N., Shiga, Y., Ohta, T., Tsuzuki, M. (2017) Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear. Marine biotechnology (New York, N.Y.). 19(5):430-440
- Nathiga Nambi, K.S., Abdul Majeed, S., Taju, G., Sivasubbu, S., Sarath Babu, V., Sahul Hameed, A.S. (2017) Effects of nicotine on zebrafish: a comparative response between a newly established gill cell line and whole gills. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 195:68-77
- Sumi, K.R., Nou, I.S., Kho, K.H. (2016) Identification and expression of a novel carbonic anhydrase isozyme in the pufferfish Takifugu vermicularis. Gene. 588(2):173-9
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Greenald, D., Jeyakani, J., Pelster, B., Sealy, I., Mathavan, S., van Eeden, F.J. (2015) Genome-wide mapping of Hif-1α binding sites in zebrafish. BMC Genomics. 16:923
- Lin, C.H., Shih, T.H., Liu, S.T., Hsu, H.H., Hwang, P.P. (2015) Cortisol Regulates Acid Secretion of H(+)-ATPase-rich Ionocytes in Zebrafish (Danio rerio) Embryos. Frontiers in Physiology. 6:328
- Tarbashevich, K., Reichman-Fried, M., Grimaldi, C., Raz, E. (2015) Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Current biology : CB. 25(8):1096-103
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