Gene
fev
- ID
- ZDB-GENE-070112-1852
- Name
- FEV transcription factor, ETS family member
- Symbol
- fev Nomenclature History
- Previous Names
-
- Pet-1 (1)
- zgc:158720
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within endothelium development; hematopoietic stem cell differentiation; and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including brain; endocrine system; presumptive blood; serotonergic neurons; and trunk. Orthologous to human FEV (FEV transcription factor, ETS family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Ets domain | ETS family | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:A0A8M9QJU5 | InterPro | 214 | ||||
UniProtKB:A0A8M9QFM3 | InterPro | 162 | ||||
UniProtKB:A3FEM2 | InterPro | 235 | ||||
UniProtKB:A1L294 | InterPro | 162 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-3.2fev:EGFP) |
|
| 1 | (13) | |
Tg(-3.2-fev:GAL4-GFP) |
|
| 1 | (3) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-69O16 | ZFIN Curated Data | |
Encodes | cDNA | MGC:158720 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191196 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001328149 (1) | 1390 nt | ||
Genomic | GenBank:CU468956 (2) | 156034 nt | ||
Polypeptide | UniProtKB:A3FEM2 (1) | 235 aa |
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
- Liu, Z.H., Li, Y.W., Hu, W., Chen, Q.L., Shen, Y.J. (2020) Mechanisms involved in tributyltin-enhanced aggressive behaviors and fear responses in male zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 220:105408
- Pijuan-Sala, B., Wilson, N.K., Xia, J., Hou, X., Hannah, R.L., Kinston, S., Calero-Nieto, F.J., Poirion, O., Preissl, S., Liu, F., Göttgens, B. (2020) Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis. Nature cell biology. 22(4):487-497
- Tu, X., Li, Y.W., Chen, Q.L., Shen, Y.J., Liu, Z.H. (2020) Tributyltin enhanced anxiety of adult male zebrafish through elevating cortisol level and disruption in serotonin, dopamine and gamma-aminobutyric acid neurotransmitter pathways. Ecotoxicology and environmental safety. 203:111014
- Jeong, I., Kim, E., Seong, J.Y., Park, H.C. (2019) Overexpression of Spexin 1 in the Dorsal Habenula Reduces Anxiety in Zebrafish. Frontiers in neural circuits. 13:53
- Yang, L., Zeng, C., Zhang, Y., Wang, F., Takamiya, M., Strähle, U. (2019) Functions of thioredoxin1 in brain development and in response to environmental chemicals in zebrafish embryos. Toxicology letters. 314:43-52
- Choi, J.H., Jeong, Y.M., Kim, S., Lee, B., Ariyasiri, K., Kim, H.T., Jung, S.H., Hwang, K.S., Choi, T.I., Park, C.O., Huh, W.K., Carl, M., Rosenfeld, J.A., Raskin, S., Ma, A., Gecz, J., Kim, H.G., Kim, J.S., Shin, H.C., Park, D.S., Gerlai, R., Jamieson, B.B., Kim, J.S., Iremonger, K.J., Lee, S.H., Shin, H.S., Kim, C.H. (2018) Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Proceedings of the National Academy of Sciences of the United States of America. 115(5):E1041-E1050
- Xiao, W.Y., Li, Y.W., Chen, Q.L., Liu, Z.H. (2018) Tributyltin impaired reproductive success in female zebrafish through disrupting oogenesis, reproductive behaviors and serotonin synthesis. Aquatic toxicology (Amsterdam, Netherlands). 200:206-216
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