Gene
aldh1a3
- ID
- ZDB-GENE-061128-2
- Name
- aldehyde dehydrogenase 1 family, member A3
- Symbol
- aldh1a3 Nomenclature History
- Previous Names
-
- Raldh3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in aldehyde metabolic process. Is expressed in several structures, including brain; immature eye; otic vesicle; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 8 | Alliance | Microphthalmia, isolated 8 | 615113 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q0H2G3 | InterPro | 513 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh1a3-201
(1)
|
Ensembl | 2,256 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044745 (1) | 1892 nt | ||
| Genomic | GenBank:CABZ01067605 (1) | 52882 nt | ||
| Polypeptide | UniProtKB:Q0H2G3 (1) | 513 aa |
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Ulhaq, Z.S., Okamoto, K., Ogino, Y., Fai Tse, W.K. (2023) Dysregulation of spliceosomes complex induces retinitis pigmentosa-like characteristics in sf3b4-depleted zebrafish. The American journal of pathology. 193(9):1223-1233
- Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J.H., Patton, E.E. (2022) Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development (Cambridge, England). 149(10):
- Fox, S.C., Widen, S.A., Asai-Coakwell, M., Havrylov, S., Benson, M., Prichard, L.B., Baddam, P., Graf, D., Lehmann, O.J., Waskiewicz, A.J. (2022) BMP3 is a novel locus involved in the causality of ocular coloboma. Human genetics. 141(8):1385-1407
- George, A., Lee, J., Liu, J., Kim, S., Brooks, B.P. (2022) Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(4):495-509
- Jiang, Z., El-Brolosy, M.A., Serobyan, V., Welker, J.M., Retzer, N., Dooley, C.M., Jakutis, G., Juan, T., Fukuda, N., Maischein, H.M., Balciunas, D., Stainier, D.Y.R. (2022) Parental mutations influence wild-type offspring via transcriptional adaptation. Science advances. 8:eabj2029
- Hsiao, T.H., Lee, G.H., Chang, Y.S., Chen, B.H., Fu, T.F. (2021) The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects. Frontiers in cell and developmental biology. 9:702969
- Leijten, N.M., Bakker, P., Spaink, H.P., den Hertog, J., Lemeer, S. (2021) Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism. Molecular & cellular proteomics : MCP. 20:100033
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Mathiyalagan, N., Miles, L.B., Anderson, P.J., Wilanowski, T., Grills, B.L., McDonald, S.J., Keightley, M.C., Charzynska, A., Dabrowski, M., Dworkin, S. (2019) Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Genes. 10(11)
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