Gene
pi4kb
- ID
- ZDB-GENE-061013-96
- Name
- phosphatidylinositol 4-kinase, catalytic, beta
- Symbol
- pi4kb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol 4-kinase activity. Acts upstream of or within cilium assembly; inner ear development; and pronephros structural organization. Predicted to be located in mitochondrial outer membrane and rough endoplasmic reticulum membrane. Predicted to be active in cytoplasm and membrane. Is expressed in brain; head; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 87. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pi4kb | Zebrafish Nomenclature Committee | |
| CRISPR2-pi4kb | (2) | |
| MO1-pi4kb | N/A | (3) |
| MO2-pi4kb | N/A | Petko et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 87 | Alliance | Deafness, autosomal dominant 87 | 620281 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| Domain | IPR049160 | PI4KB/PIK1, accessory domain |
| Family | IPR015433 | Phosphatidylinositol kinase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | PI4KB/PIK1, accessory domain | Protein kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RBR8 | InterPro | 850 | |||||||
| UniProtKB:A0A8M2B4L5 | InterPro | 848 | |||||||
| UniProtKB:Q49GP3 | InterPro | 835 | |||||||
| UniProtKB:A0AB32T9K1 | InterPro | 833 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pi4kb | monoclonal | IgG2a | Mouse |
|
BD Biosciences
|
4 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-23O4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152715 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198343 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001034977 (1) | 3570 nt | ||
| Genomic | GenBank:BX005412 (1) | 250962 nt | ||
| Polypeptide | UniProtKB:F1RBR8 (1) | 850 aa |
- Fullone, M.R., Maftei, D., Vincenzi, M., Lattanzi, R., Miele, R. (2024) MRAP2a Binds and Modulates Activity and Localisation of Prokineticin Receptor 1 in Zebrafish. International Journal of Molecular Sciences. 25(14):
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Feng, Y., Zhang, J., Li, Y., Chen, G., Zhang, X., Ning, G., Wu, S. (2023) Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1. Gene. 898:148105
- Lu, L., Liu, Q., Zhi, L., Che, X., Xiao, B., Cui, M., Yu, M., Yang, B., Zhang, J., Zhang, B. (2021) Establishment of a Ciliogenesis-Associated Signaling Model for Polycystic Kidney Disease. Kidney & blood pressure research. 46(6):693-701
- Feng, Y., Yu, P., Li, J., Cao, Y., Zhang, J. (2020) Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle. Journal of genetics and genomics = Yi chuan xue bao. 47(10):627-636
- Su, X., Feng, Y., Rahman, S.A., Wu, S., Li, G., Rüschendorf, F., Zhao, L., Cui, H., Liang, J., Fang, L., Hu, H., Froehler, S., Yu, Y., Patone, G., Hummel, O., Chen, Q., Raile, K., Luft, F.C., Bähring, S., Hussain, K., Chen, W., Zhang, J., Gong, M. (2020) Phosphatidylinositol 4-kinase β mutations cause nonsyndromic sensorineural deafness and inner ear malformation. Journal of genetics and genomics = Yi chuan xue bao. 47(10):618-626
- Ma, H., Blake, T., Chitnis, A., Liu, P., and Balla, T. (2009) Crucial role of phosphatidylinositol 4-kinase III{alpha} in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling. Journal of Cell Science. 122(Pt 23):4303-4310
- Petko, J.A., Kabbani, N., Frey, C., Woll, M., Hickey, K., Craig, M., Canfield, V.A., and Levenson, R. (2009) Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neuroscience. 10:27
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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