Gene
cnga2a
- ID
- ZDB-GENE-061005-1
- Name
- cyclic nucleotide gated channel subunit alpha 2a
- Symbol
- cnga2a Nomenclature History
- Previous Names
-
- cnga5
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables monoatomic ion channel activity. Acts upstream of or within cilium assembly and monoatomic ion transport. Located in membrane. Is expressed in brain; olfactory epithelium; spinal cord; and testis. Orthologous to human CNGA2 (cyclic nucleotide gated channel subunit alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shim et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018821Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22446 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22447 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35663 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| wz09 | Allele with one delins | Unknown | Unknown | CRISPR | |
| wz10 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cnga2a | (2) | |
| CRISPR2-cnga2a | (2) | |
| MO1-cnga2a | N/A | Shim et al., 2016 |
| MO2-cnga2a | N/A | Shim et al., 2016 |
| MO3-cnga2a | N/A | Blechman et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR032406 | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain |
| Family | IPR050866 | Cyclic nucleotide-gated cation channel |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Cyclic nucleotide-gated cation channel | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | Ion transport domain | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q0GFG2 | InterPro | 673 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cnga2a-201
(1)
|
Ensembl | 2,105 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-86A12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044746 (1) | 2105 nt | ||
| Genomic | GenBank:CR376767 (2) | 167993 nt | ||
| Polypeptide | UniProtKB:Q0GFG2 (1) | 673 aa |
- Blechman, J., Anbalagan, S., Matthews, G.G., Levkowitz, G. (2018) Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin. Frontiers in cell and developmental biology. 6:117
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Khan, S., Perry, C., Tetreault, M.L., Henry, D., Trimmer, J.S., Zimmerman, A.L., and Matthews, G. (2010) A novel cyclic nucleotide-gated ion channel enriched in synaptic terminals of isotocin neurons in zebrafish brain and pituitary. Neuroscience. 165(1):79-89
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Tetreault, M.L., Henry, D., Horrigan, D.M., Matthews, G., and Zimmerman, A.L. (2006) Characterization of a novel cyclic nucleotide-gated channel from zebrafish brain. Biochemical and Biophysical Research Communications. 348(2):441-449
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