Gene
manf
- ID
- ZDB-GENE-060929-640
- Name
- mesencephalic astrocyte-derived neurotrophic factor
- Symbol
- manf Nomenclature History
- Previous Names
-
- im:6909481
- zgc:153327
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Acts upstream of or within dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in several structures, including axis; brain; hatching gland; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909481 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chen et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37559 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diabetes, deafness, developmental delay, and short stature syndrome | 620651 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ARMET, C-terminal | ARMET-like | ARMET, N-terminal | SAP domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q08CA7 | InterPro | 180 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-manf | polyclonal | IgG | Rabbit |
|
ProSci Incorporated
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-167F18 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909481 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:153327 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192134 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001076629 (1) | 1109 nt | ||
| Genomic | GenBank:CU856621 (1) | 95091 nt | ||
| Polypeptide | UniProtKB:Q08CA7 (1) | 180 aa |
- Eghan, K., Lee, S., Yoo, D., Kim, W.K. (2025) 2-Ethylhexanol induces autism-like neurobehavior and neurodevelopmental disorders in zebrafish. Journal of hazardous materials. 488:137469137469
- Kalyn, M., Garvey, R., Lee, H., Mbesha, H.A., Curry, J., Saxena, V., Mennigen, J.A., Ekker, M. (2024) Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish. Journal of neurochemistry. :
- Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Baronio, D., Chen, Y.C., Decker, A.R., Enckell, L., Fernández-López, B., Semenova, S., Puttonen, H.A.J., Cornell, R.A., Panula, P. (2021) Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish. Acta physiologica (Oxford, England). 234(1):e13725
- Niu, X., Xu, S., Yang, Q., Xu, X., Zheng, M., Li, X., Guan, W. (2021) Toxic effects of the dinoflagellate Karenia mikimotoi on zebrafish (Danio rerio) larval behavior. Harmful algae. 103:101996
- Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X., Wang, S., Xu, S., Zheng, M., Huang, J., Wan, X., Guan, W., Su, K.P., Ye, M., Gao, X., Yin, Z., Li, X. (2021) Ghrelin Modulates Dopaminergic Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models. Brain, behavior, and immunity. 94:327-337
- Chen, Y.C., Baronio, D., Semenova, S., Abdurakhmanova, S., Panula, P. (2020) Cerebral Dopamine Neurotrophic Factor regulates multiple neuronal subtypes and behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(32):6146-6164
- Jia, M., Teng, M., Tian, S., Yan, J., Meng, Z., Yan, S., Li, R., Zhou, Z., Zhu, W. (2020) Developmental toxicity and neurotoxicity of penconazole enantiomers exposure on zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 267:115450
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