Gene
plvapb
- ID
- ZDB-GENE-060616-96
- Name
- plasmalemma vesicle associated protein b
- Symbol
- plvapb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Acts upstream of or within Notch signaling pathway and regulation of vascular permeability. Predicted to be located in membrane. Is expressed in vasculature. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Gordon et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Diarrhea 10, protein-losing enteropathy type | 618183 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR009538 | Plasmalemma vesicle-associated protein |
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Domain Details Per Protein
Protein | Additional Resources | Length | Plasmalemma vesicle-associated protein |
---|---|---|---|
UniProtKB:F1Q8W5 | InterPro | 409 | |
UniProtKB:Q1ED33 | InterPro | 409 | |
UniProtKB:Q58EJ6 | InterPro | 409 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
plvapb-201
(1)
|
Ensembl | 2,019 nt | ||
ncRNA |
vsg1-002
(1)
|
Ensembl | 725 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(plvapb:EGFP) |
|
| 1 | (5) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-67M7 | ZFIN Curated Data | |
Encodes | EST | fb11a07 | ||
Encodes | cDNA | MGC:113451 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136228 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192924 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001030244 (1) | 1982 nt | ||
Genomic | GenBank:BX255969 (2) | 155717 nt | ||
Polypeptide | UniProtKB:F1Q8W5 (1) | 409 aa |
- Moleri, S., Mercurio, S., Pezzotta, A., D'Angelo, D., Brix, A., Plebani, A., Lini, G., Di Fuorti, M., Beltrame, M. (2023) Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression. Cells. 12(18):
- O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G. (2023) The secreted neuronal signal spock1 promotes blood-brain barrier development. Developmental Cell. 58(17):1534-1547.e6
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Gordon, L., Blechman, J., Shimoni, E., Gur, D., Anand-Apte, B., Levkowitz, G. (2019) Fenestrae-associated protein Plvap regulates the rate of blood-borne proteins passage into the hypophysis. Development (Cambridge, England). 146(23):
- Anbalagan, S., Gordon, L., Blechman, J., Matsuoka, R.L., Rajamannar, P., Wircer, E., Biran, J., Reuveny, A., Leshkowitz, D., Stainier, D.Y.R., Levkowitz, G. (2018) Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces. Developmental Cell. 47(6):711-726.e5
- Umans, R.A., Henson, H.E., Mu, F., Parupalli, C., Ju, B., Peters, J.L., Lanham, K.A., Plavicki, J.S., Taylor, M.R. (2017) CNS angiogenesis and barriergenesis occur simultaneously. Developmental Biology. 425(2):101-108
- Xu, B., Zhang, Y., Du, X.F., Li, J., Zi, H.X., Bu, J.W., Yan, Y., Han, H., Du, J.L. (2017) Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Cell Research. 27(7):882-897
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Ulrich, F., Carretero-Ortega, J., Menéndez, J., Narvaez, C., Sun, B., Lancaster, E., Pershad, V., Trzaska, S., Véliz, E., Kamei, M., Prendergast, A., Kidd, K.R., Shaw, K.M., Castranova, D.A., Pham, V.N., Lo, B.D., Martin, B.L., Raible, D.W., Weinstein, B.M., Torres-Vazquez, J. (2016) Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development (Cambridge, England). 143(1):147-59
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
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