Gene
slc9a3.2
- ID
- ZDB-GENE-060503-640
- Name
- solute carrier family 9 member A3, tandem duplicate 2
- Symbol
- slc9a3.2 Nomenclature History
- Previous Names
-
- nhe3b (1)
- si:dkey-3n22.6
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables sodium:proton antiporter activity. Acts upstream of or within ammonium transmembrane transport; sodium ion homeostasis; and sodium ion import across plasma membrane. Located in apical plasma membrane. Is expressed in gill; integument; and renal system. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc9a3.2 | (3) | |
| MO1-slc9a3.2 | N/A | (4) |
| MO2-slc9a3.2 | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital secretory sodium diarrhea 8 | Alliance | Diarrhea 8, secretory sodium, congenital | 616868 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation/H+ exchanger, CPA1 family | Cation/H+ exchanger, transmembrane domain | Na+/H+ exchanger | Na+/H+ exchanger, isoforms 3/5 |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASE1 | InterPro | 845 | ||||
| UniProtKB:A9XP97 | InterPro | 851 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc9a3.2-201
(1)
|
Ensembl | 2,796 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-slc9a3.2 | polyclonal | Rat |
|
2 | |||
| Ab2-slc9a3.2 | polyclonal | Rabbit |
|
1 | |||
| Ab4-slc9a3.2 | Rabbit |
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-3N22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113479 (1) | 2831 nt | ||
| Genomic | GenBank:BX005424 (2) | 200523 nt | ||
| Polypeptide | UniProtKB:A9XP97 (1) | 851 aa |
- Abu Obaid, A., Ivandic, I., Korsching, S.I. (2024) Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis. Cellular and molecular life sciences : CMLS. 81:213213
- Cazorla-Vázquez, S., Kösters, P., Bertz, S., Pfister, F., Daniel, C., Dedden, M., Zundler, S., Jobst-Schwan, T., Amann, K., Engel, F.B. (2023) Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney. Cells. 12(15):
- Shih, S.W., Yan, J.J., Tsou, Y.L., Lu, S.W., Wang, M.C., Chou, M.Y., Hwang, P.P. (2022) In Vivo Functional Assay in Fish Gills: Exploring Branchial Acid-Excreting Mechanisms in Zebrafish. International Journal of Molecular Sciences. 23(8):
- Lee, C.Y., Horng, J.L., Liu, S.T., Lin, L.Y. (2020) Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos. Chemosphere. 261:128051
- Shir-Mohammadi, K., Perry, S.F. (2020) Expression of ion-transport genes in ionocytes isolated from larval zebrafish (Danio rerio) exposed to acidic or Na+ deficient water. American journal of physiology. Regulatory, integrative and comparative physiology. 319(4):R412-R427
- Tong, S.K., Lee, H.L., Lee, Y.C., Wu, L.C., Tsou, Y.L., Lu, S.W., Shih, S.W., Hwang, P.P., Chou, M.Y. (2020) Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes. International Journal of Molecular Sciences. 21(11)
- Yew, H.M., Zimmer, A.M., Perry, S.F. (2020) Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging. The Journal of experimental biology. 223(Pt 5):
- Zimmer, A.M., Perry, S.F. (2020) The Rhesus glycoprotein Rhcgb is expendable for ammonia excretion and Na+ uptake in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 247:110722
- Zimmer, A.M., Shir-Mohammadi, K., Kwong, R.W.M., Perry, S.F. (2020) Reassessing the contribution of the Na+/H+ exchanger Nhe3b to Na+ uptake in zebrafish (Danio rerio) using CRISPR/Cas9 gene editing. The Journal of experimental biology. 223(Pt 2)
- Shu, T., Shu, Y., Gao, Y., Jin, X., He, J., Zhai, G., Yin, Z. (2018) Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. Frontiers in endocrinology. 9:683
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