Gene
dmc1
- ID
- ZDB-GENE-060331-93
- Name
- DNA meiotic recombinase 1
- Symbol
- dmc1 Nomenclature History
- Previous Names
-
- zgc:136628
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Predicted to be involved in DNA recombination and chromosome organization involved in meiotic cell cycle. Predicted to act upstream of or within DNA repair and meiotic cell cycle. Predicted to be located in nucleus. Predicted to be active in condensed nuclear chromosome. Is expressed in ovary; spermatocyte; and testis. Orthologous to human DMC1 (DNA meiotic recombinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dmc1 | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| Domain | IPR020587 | DNA recombination and repair protein RecA, monomer-monomer interface |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Family | IPR011940 | Meiotic recombination protein Dmc1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | DNA recombination and repair protein Rad51-like, C-terminal | DNA recombination and repair protein, RecA-like | DNA recombination and repair protein RecA-like, ATP-binding domain | DNA recombination and repair protein RecA, monomer-monomer interface | DNA repair Rad51/transcription factor NusA, alpha-helical | Meiotic recombination protein Dmc1 | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q50LF4 | InterPro | 342 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:dmc1-IRES-EGFP) |
| 1 | Xie et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16I5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136628 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194181 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020782 (1) | 1324 nt | ||
| Genomic | GenBank:BX649366 (1) | 222310 nt | ||
| Polypeptide | UniProtKB:Q50LF4 (1) | 342 aa |
- Fung, L., Dranow, D.B., Subramanian, A., Libby, N., Schilling, T.F. (2024) Cellular retinoic acid binding proteins regulate germ cell proliferation and sex determination in zebrafish. Development (Cambridge, England). 151(24):
- Ou, Y., Li, H., Li, J., Dai, X., He, J., Wang, S., Liu, Q., Yang, C., Wang, J., Zhao, R., Yin, Z., Shu, Y., Liu, S. (2024) Formation of different polyploids through disrupting meiotic crossover frequencies based on cntd1 knockout in zebrafish. Molecular Biology and Evolution. 41(3):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Pan, Y.J., Tong, S.K., Hsu, C.W., Weng, J.H., Chung, B.C. (2022) Zebrafish Establish Female Germ Cell Identity by Advancing Cell Proliferation and Meiosis. Frontiers in cell and developmental biology. 10:866267
- Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z., Yin, Z. (2021) Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of reproduction. 104(5):1139-1153
- Lan, X.R., Li, Y.W., Chen, Q.L., Shen, Y.J., Liu, Z.H. (2020) Tributyltin impaired spermatogenesis and reproductive behavior in male zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 224:105503
- Liang, Y.Q., Jing, Z., Pan, C.G., Lin, Z., Zhen, Z., Hou, L., Dong, Z. (2020) The progestin norethindrone alters growth, reproductive histology and gene expression in zebrafish (Danio rerio). Chemosphere. 242:125285
- Takemoto, K., Imai, Y., Saito, K., Kawasaki, T., Carlton, P.M., Ishiguro, K.I., Sakai, N. (2020) Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes. PLoS Genetics. 16:e1008640
- Xie, D., Chen, Q., Gong, S., An, J., Li, Y., Lian, X., Liu, Z., Shen, Y., Giesy, J.P. (2020) Exposure of zebrafish to environmentally relevant concentrations of mercury during early life stages impairs subsequent reproduction in adults but can be recovered in offspring. Aquatic toxicology (Amsterdam, Netherlands). 229:105655
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
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