Gene
wwtr1
- ID
- ZDB-GENE-051101-1
- Name
- WW domain containing transcription regulator 1
- Symbol
- wwtr1 Nomenclature History
- Previous Names
-
- taz (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable transcription coactivator activity and transcription corepressor activity. Involved in regulation of gene expression. Acts upstream of with a positive effect on BMP signaling pathway. Acts upstream of or within several processes, including Kupffer's vesicle development; anterior/posterior pattern specification involved in pronephros development; and circulatory system development. Predicted to be located in bicellular tight junction. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; endocrine system; gut; head; and liver and biliary system. Orthologous to human WWTR1 (WW domain containing transcription regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns35 | Allele with one insertion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| fu55 | Allele with one delins | Unknown | Unknown | TALEN | |
| mw49 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| ncv114 | Allele with one deletion | Exon 1 | Premature Stop | TALEN | |
| swu46 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| swu47 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| umo55 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| umo70 | Allele with one insertion | Unknown | Premature Stop | CRISPR | |
| va4 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | WW domain | WW domain superfamily | Yes-associated protein 1 |
|---|---|---|---|---|---|
| UniProtKB:Q307I6 | InterPro | 391 | |||
| UniProtKB:A0A8M2B8N9 | InterPro | 390 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-wwtr1 | monoclonal | IgG | Rabbit |
|
Cell Signaling Technology, Inc.
|
22 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(14xUAS:DsRed,NLS-dnwwtr1) |
| 1 | Miesfeld et al., 2015 | ||
| Tg(14xUAS:DsRed,wwtr1) |
|
| 1 | (3) | |
| Tg(cdh17:mCherry-2A-wwtr1_S79A) |
| 1 | Zebrafish Nomenclature Committee | ||
| Tg(CMV:cawwtr1_S79A,GFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-197B13 | ZFIN Curated Data | |
| Contained in | BAC | CH73-387F7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193975 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193988 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037696 (1) | 1401 nt | ||
| Genomic | GenBank:CU468731 (1) | 93652 nt | ||
| Polypeptide | UniProtKB:Q307I6 (1) | 391 aa |
- Dicipulo, R., Selland, L.G., Carpenter, R.G., Waskiewicz, A.J. (2025) Functional role for Taz during hindbrain ventricle morphogenesis. PLoS One. 20:e0313262e0313262
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Dai, C., Zhang, Y., Gong, Y., Bradley, A., Tang, Z., Sellick, K., Shrestha, S., Spears, E., Covington, B.A., Stanley, J., Jenkins, R., Richardson, T.M., Brantley, R.A., Coate, K., Saunders, D.C., Wright, J.J., Brissova, M., Dean, E.D., Powers, A.C., Chen, W. (2024) Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways. iScience. 27:111447111447
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967
- Lai, J.K.H., Toh, P.J.Y., Cognart, H.A., Chouhan, G., Saunders, T.E. (2022) DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells. eLIFE. 11:
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- He, L., Zhang, Q., Jiang, D., Zhang, Y., Wei, Y., Yang, Y., Li, N., Wang, S., Yue, Y., Zhao, Q. (2021) Zebrafish foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression. Journal of genetics and genomics = Yi chuan xue bao. 49(6):559-568
- Ren, Z., Zhang, Z., Liu, T.M., Ge, W. (2021) Novel zebrafish polycystic kidney disease (PKD) models reveal functions of the Hippo pathway in renal cystogenesis. Disease models & mechanisms. 14(11):
- Brandt, Z.J., Echert, A.E., Bostrom, J.R., North, P.N., Link, B.A. (2020) Core Hippo pathway components act as a brake on Yap/Taz in the development and maintenance of the biliary network. Development (Cambridge, England). 147(12):
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