Gene
itga2b
- ID
- ZDB-GENE-051031-1
- Name
- integrin, alpha 2b
- Symbol
- itga2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within angiogenesis; blood coagulation; and endothelial cell proliferation. Part of integrin complex. Is expressed in blood; retina; thrombocyte; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa19 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa83 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa10134 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa26046 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa30831 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40051 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa40052 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40053 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-itga2b | N/A | O'Connor et al., 2009 |
MO2-itga2b | N/A | O'Connor et al., 2009 |
MO3-itga2b | N/A | Kim et al., 2010 |
MO4-itga2b | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Glanzmann's thrombasthenia | Alliance | Glanzmann thrombasthenia 1 | 273800 |
platelet-type bleeding disorder 16 | Alliance | Bleeding disorder, platelet-type, 16, autosomal dominant | 187800 |
Thrombocytopenia, neonatal alloimmune, BAK antigen related |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
Family | IPR000413 | Integrin alpha chain |
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Domain Details Per Protein
Protein | Additional Resources | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6EIY7 | InterPro | 1037 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
itga2b-201
(1)
|
Ensembl | 3,755 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab3-itga2b | monoclonal | Mouse |
|
1 | |||
Ab1-itga2b | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-6.0itga2b:EGFP) |
|
| 1 | (229) | |
Tg(itga2b:GFP) |
|
| 1 | Zhang et al., 2017 | |
Tg(itga2b:mCherry-mir126a,myl7:EGFP) |
|
| 1 | Zapilko et al., 2020 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-54A8 | ||
Encodes | cDNA | MGC:194612 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001003857 (1) | 3673 nt | ||
Genomic | GenBank:CT573446 (2) | 75900 nt | ||
Polypeptide | UniProtKB:Q6EIY7 (1) | 1037 aa |
- Spampinato, M., Giallongo, C., Giallongo, S., Spina, E., Duminuco, A., Longhitano, L., Caltabiano, R., Salvatorelli, L., Broggi, G., Pricoco, E.P., Del Fabro, V., Dulcamare, I., DI Mauro, A.M., Romano, A., Di Raimondo, F., Li Volti, G., Palumbo, G.A., Tibullo, D. (2025) Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis. Journal of translational medicine. 23:6969
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Griffin, M.S., Dahlgren, A.R., Nagaswami, C., Litvinov, R.I., Keeler, K., Madenjian, C., Fuentes, R., Fish, R.J., Neerman-Arbez, M., Holinstat, M., Adili, R., Weisel, J.W., Shavit, J.A. (2023) Composition of thrombi in zebrafish: similarities and distinctions with mammals. Journal of thrombosis and haemostasis : JTH. 22(4):1056-1068
- Li, W., Wen, L., Rathod, B., Gingras, A.C., Ley, K., Lee, H.S. (2022) Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development. Life science alliance. 6(3):
- Li, X., Liu, X., Xing, Y., Zeng, L., Liu, X., Shen, H., Ma, J. (2022) Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction. Investigative ophthalmology & visual science. 63:27
- Yang, L., Wu, L., Meng, P., Zhang, X., Zhao, D., Lin, Q., Zhang, Y. (2022) Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish. Journal of thrombosis and haemostasis : JTH. 20(8):1900-1909
- Belmonte, R.L., Engbretson, I.L., Kim, J.H., Cajias, I., Ahn, E.E., Stachura, D.L. (2021) son is necessary for proper vertebrate blood development. PLoS One. 16:e0247489
- Bresciani, E., Carrington, B., Yu, K., Kim, E.M.K., Zhen, T., Guzman, V.S., Broadbridge, E., Bishop, K., Kirby, M., Harper, U., Wincovitch, S., Dell'Orso, S., Sartorelli, V., Sood, R., Liu, P.P. (2021) Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. Blood advances. 5(23):4949-4962
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