Gene
bcl2a
- ID
- ZDB-GENE-051012-1
- Name
- BCL2 apoptosis regulator a
- Symbol
- bcl2a Nomenclature History
- Previous Names
-
- bcl2
- zBlp2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including anterior lateral mesoderm; corpuscles of Stannius; digestive system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 53 figures from 47 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-bcl2a | N/A | Kratz et al., 2006 |
| MO2-bcl2a | N/A | O'Hare et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukemia/lymphoma, B-cell, 2 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site |
| Conserved_site | IPR020726 | Apoptosis regulator, Bcl-2, BH2 motif, conserved site |
| Domain | IPR003093 | Apoptosis regulator, Bcl-2 protein, BH4 |
| Domain | IPR046371 | Bcl-2, Bcl-2 homology region 1-3 |
| Family | IPR002475 | Bcl2-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2, BH2 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q564A4 | InterPro | 228 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Gt2(bcl2a-EGFP) |
|
| 3 | (9) | |
| Gt(bcl2a-EGFP) |
|
| 5 | (17) | |
| Tg(hsp70l:bcl2a-2A-CAAX-EGFP) |
| 1 | Atieh et al., 2020 | ||
| Tg(hsp70l:GFP-bcl2a) |
|
| 1 | Matsumoto et al., 2024 | |
| Tg(hsp70l:mCherry-bcl2a) |
|
| 1 | (3) | |
| Tg(hsp70l:mCherry-bcl2a-ERLS) |
| 1 | Nishiwaki et al., 2020 | ||
| Tg(myo6b:EGFP-bcl2a,myl7:EGFP) |
|
| 1 | (3) | |
| Tg(rag2:EGFP-bcl2a) |
|
| 1 | (12) | |
| Tg(rag2:mCherry-bcl2a) |
|
| 1 | Harrold et al., 2016 | |
| Tg(Xla.Tubb2b:bcl2a) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-74B21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-121F17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162054 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030253 (1) | 1150 nt | ||
| Genomic | GenBank:CU695001 (1) | 93715 nt | ||
| Polypeptide | UniProtKB:Q564A4 (1) | 228 aa |
- Dhiman, P., Kumar, R., Singh, D. (2025) Neuronal nitric oxide synthase activation by tadalafil protects neurological impairments in a zebrafish larva model of hyperammonemia. Life sciences. 361:123325123325
- Huang, J., Li, L., Xu, L., Feng, L., Wang, Y., Sik, A.G., Jin, M., Wang, R., Liu, K., Li, X. (2025) Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways. Marine drugs. 23:
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Madesh, S., Murugan, R., Sau, A., Jubie, S., Swaroop, A.K., Rajagopal, R., Kumaradoss, K.M., Arockiaraj, J. (2025) Nano-Encapsulated Coumarin Derivative, CS-QM2 Inhibits Neoplasm Growth: Experimented in Zebrafish Model. Journal of biochemical and molecular toxicology. 39:e70239e70239
- Wang, X., Liu, M., Zhang, Y., Ma, D., Wang, L., Liu, F. (2025) Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 122:e2420534122e2420534122
- Belt, A.J., Grant, S., Tombes, R.M., Rothschild, S.C. (2024) Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos. PLoS Genetics. 20:e1011308e1011308
- Chiang, H.J., Nishiwaki, Y., Chiang, W.C., Masai, I. (2024) Male germ cell-associated kinase (MAK) is required for axoneme formation during ciliogenesis in zebrafish photoreceptors. Disease models & mechanisms. 17(7):
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Li, K., Fan, D., Zhou, J., Zhao, Z., Han, A., Song, Z., Tang, X., Hu, B. (2024) Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43. International Journal of Molecular Sciences. 25(20):
- Lin, J., Li, X., Lu, K., Song, K., Wang, L., Dai, W., Mohamed, M., Zhang, C. (2024) Low phosphorus causes hepatic energy metabolism disorder through Dynamin-related protein 1-mediated mitochondrial fission in fish. The Journal of nutrition. 155(1):132-152
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