Gene
mpi
- ID
- ZDB-GENE-050904-6
- Name
- mannose phosphate isomerase
- Symbol
- mpi Nomenclature History
- Previous Names
-
- im:7140016
- zgc:110773
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables mannose-6-phosphate isomerase activity. Acts upstream of or within chondrocyte morphogenesis; chordate embryonic development; and liver development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including female organism; margin; nervous system; neural tube; and polster. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140016 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-mpi | (2) | |
CRISPR2-mpi | (2) | |
MO1-mpi | N/A | (5) |
TALEN1-mpi | (4) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
congenital disorder of glycosylation Ib | Alliance | Congenital disorder of glycosylation, type Ib | 602579 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
congenital disorder of glycosylation type I | AB + MO1-mpi | standard conditions | Chu et al., 2013 |
congenital disorder of glycosylation type I | WT + MO1-mpi | standard conditions | DeRossi et al., 2019 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018050 | Phosphomannose isomerase, type I, conserved site |
Domain | IPR046456 | Phosphomannose isomerase type I, C-terminal domain |
Domain | IPR046457 | Phosphomannose isomerase type I, catalytic domain |
Domain | IPR046458 | Phosphomannose isomerase type I, helical insertion domain |
Family | IPR001250 | Mannose-6-phosphate isomerase, type I |
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Domain Details Per Protein
Protein | Additional Resources | Length | Mannose-6-phosphate isomerase | Mannose-6-phosphate isomerase, type I | Phosphomannose isomerase type I, catalytic domain | Phosphomannose isomerase, type I, conserved site | Phosphomannose isomerase type I, C-terminal domain | Phosphomannose isomerase type I, helical insertion domain | RmlC-like cupin domain superfamily | RmlC-like jelly roll fold |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q3ZB95 | InterPro | 422 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-232C9 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-296I8 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7140016 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:110773 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001033110 (1) | 1515 nt | ||
Genomic | GenBank:CU651670 (1) | 38908 nt | ||
Polypeptide | UniProtKB:Q3ZB95 (1) | 422 aa |
- Morrison, J.K., DeRossi, C., Alter, I.L., Nayar, S., Giri, M., Zhang, C., Cho, J.H., Chu, J. (2022) Single-cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver. Hepatology communications. 6(7):1711-1724
- DeRossi, C., Bambino, K., Morrison, J., Sakarin, I., Villacorta-Martin, C., Zhang, C., Ellis, J.L., Fiel, M.I., Ybanez, M., Lee, Y.A., Huang, K.L., Yin, C., Sakaguchi, T.F., Friedman, S.L., Villanueva, A., Chu, J. (2019) Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. Hepatology (Baltimore, Md.). 70(6):2107-2122
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- DeRossi, C., Shtraizent, N., Nayar, S., Sachidanandam, R., Katz, L.S., Prince, A., Koh, A.P., Vincek, A., Hadas, Y., Hoshida, Y., Scott, D.K., Eliyahu, E., Freeze, H.H., Sadler, K.C., Chu, J. (2017) MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. eLIFE. 6
- Sun, Q., Liu, X., Gong, B., Wu, D., Meng, A., Jia, S. (2017) Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. International journal of biological sciences. 13:1051-1066
- DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imrie, D., Nayar, S., Baryshnikova, A., Milev, M.P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H.H., Lehrman, M.A., Sacher, M., Sadler, K.C. (2016) trappc11 is required for protein glycosylation in zebrafish and humans. Molecular biology of the cell. 27(8):1220-34
- Kent, B., Magnani, E., Walsh, M.J., Sadler, K.C. (2016) UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development. Developmental Biology. 412(1):99-113
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Chu, J., Mir, A., Gao, N., Rosa, S., Monson, C., Sharma, V., Steet, R., Freeze, H.H., Lehrman, M.A., and Sadler, K.C. (2013) A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation. Disease models & mechanisms. 6(1):95-105
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