Gene

mpi

ID
ZDB-GENE-050904-6
Name
mannose phosphate isomerase
Symbol
mpi Nomenclature History
Previous Names
  • im:7140016
  • zgc:110773
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Enables mannose-6-phosphate isomerase activity. Acts upstream of or within chondrocyte morphogenesis; chordate embryonic development; and liver development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including female organism; margin; nervous system; neural tube; and polster. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
mss7Allele with one delinsExon 2UnknownTALEN
mss14Allele with one deletionExon 3UnknownCRISPR
1 - 2 of 2
Show
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-mpi (2)
CRISPR2-mpi (2)
MO1-mpiN/A (5)
TALEN1-mpi (4)
1 - 4 of 4
Show
Human Disease
Associated With mpi Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital disorder of glycosylation Ib Alliance Congenital disorder of glycosylation, type Ib 602579
1 - 1 of 1
Associated With mpi Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018050 Phosphomannose isomerase, type I, conserved site
Domain IPR046456 Phosphomannose isomerase type I, C-terminal domain
Domain IPR046457 Phosphomannose isomerase type I, catalytic domain
Domain IPR046458 Phosphomannose isomerase type I, helical insertion domain
Family IPR001250 Mannose-6-phosphate isomerase, type I
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length Mannose-6-phosphate isomerase Mannose-6-phosphate isomerase, type I Phosphomannose isomerase type I, catalytic domain Phosphomannose isomerase, type I, conserved site Phosphomannose isomerase type I, C-terminal domain Phosphomannose isomerase type I, helical insertion domain RmlC-like cupin domain superfamily RmlC-like jelly roll fold
UniProtKB:Q3ZB95 InterPro 422
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mpi-201 (1) Ensembl 1,503 nt
mRNA mpi-202 (1) Ensembl 1,656 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mpi polyclonal Rabbit
  • IHC
1
1 - 1 of 1
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-232C9ZFIN Curated Data
Contained inFosmidCH1073-296I8ZFIN Curated Data
EncodesESTIMAGE:7140016Thisse et al., 2004
EncodescDNAMGC:110773ZFIN Curated Data
1 - 4 of 4
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMPI15
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseMpi9
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 13
Show