Gene

aldoca

ID
ZDB-GENE-050706-128
Name
aldolase C, fructose-bisphosphate, a
Symbol
aldoca Nomenclature History
Previous Names
  • aldocl (1)
  • wu:fj56h04
  • zebrin II (1)
  • zgc:112357
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytosol. Is expressed in brain. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
nub100Allele with one deletionExon 3UnknownCRISPR
sa8894Allele with one point mutationUnknownSplice SiteENU
sa35835Allele with one point mutationUnknownPremature StopENU
sa45532Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With aldoca Human Ortholog
No data available
Associated With aldoca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Conserved_site IPR029768 Fructose-bisphosphate aldolase class-I active site
Domain IPR000719 Protein kinase domain
Domain IPR045270 Serine/Threonine Kinase AGC, catalytic domain
Family IPR000741 Fructose-bisphosphate aldolase, class-I
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Domain Details Per Protein
Protein Additional Resources Length Aldolase-type TIM barrel Fructose-bisphosphate aldolase, class-I Fructose-bisphosphate aldolase class-I active site Protein kinase domain Protein kinase-like domain superfamily Serine/Threonine Kinase AGC, catalytic domain Serine/threonine-protein kinase, active site
UniProtKB:Q4KMC8 InterPro 364
UniProtKB:F1QC70 InterPro 364
UniProtKB:A0AB32T8F5 InterPro 662
UniProtKB:A0AB32TA60 InterPro 692
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA aldoca-201 (1) Ensembl 2,174 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-aldoc monoclonal Mouse
  • IHC
21
1 - 1 of 1
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg2(aldoca:BoTxBLC-GFP)
  • aldoca
  • Danio rerio
1 (3)
Tg(aldoca:BoTxBLC-GFP)
  • aldoca
  • Danio rerio
1Chang et al., 2020
Tg(aldoca:EnvA,myl7:mCherry)
  • Danio rerio
1Dohaku et al., 2019
Tg(aldoca:GAL4FF)
  • aldoca
  • Danio rerio
1 (5)
Tg(aldoca:GAP-mCherry)
  • aldoca
  • Danio rerio
1 (3)
Tg(aldoca:GAP-Venus)
  • aldoca
  • Danio rerio
2 (13)
Tg(aldoca:NTR-TagRFPT)
  • aldoca
  • Danio rerio
1 (2)
Tg(aldoca:Tva-mCherry)
  • aldoca
  • Danio rerio
1Dohaku et al., 2019
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEYP-118E10ZFIN Curated Data
EncodesESTfj56h04ZFIN Curated Data
EncodescDNAMGC:112357ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanALDOC17
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseAldoc11
Amino acid sequence comparison (1)
Citations
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