Gene
aldoca
- ID
- ZDB-GENE-050706-128
- Name
- aldolase C, fructose-bisphosphate, a
- Symbol
- aldoca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytosol. Is expressed in brain. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Conserved_site | IPR029768 | Fructose-bisphosphate aldolase class-I active site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR045270 | Serine/Threonine Kinase AGC, catalytic domain |
Family | IPR000741 | Fructose-bisphosphate aldolase, class-I |
1 - 5 of 7 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Aldolase-type TIM barrel | Fructose-bisphosphate aldolase, class-I | Fructose-bisphosphate aldolase class-I active site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine Kinase AGC, catalytic domain | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q4KMC8 | InterPro | 364 | |||||||
UniProtKB:F1QC70 | InterPro | 364 | |||||||
UniProtKB:A0AB32T8F5 | InterPro | 662 | |||||||
UniProtKB:A0AB32TA60 | InterPro | 692 |
1 - 4 of 4
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
aldoca-201
(1)
|
Ensembl | 2,174 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg2(aldoca:BoTxBLC-GFP) |
|
| 1 | (3) | |
Tg(aldoca:BoTxBLC-GFP) |
|
| 1 | Chang et al., 2020 | |
Tg(aldoca:EnvA,myl7:mCherry) |
|
| 1 | Dohaku et al., 2019 | |
Tg(aldoca:GAL4FF) |
|
| 1 | (5) | |
Tg(aldoca:GAP-mCherry) |
|
| 1 | (3) | |
Tg(aldoca:GAP-Venus) |
|
| 2 | (13) | |
Tg(aldoca:NTR-TagRFPT) |
|
| 1 | (2) | |
Tg(aldoca:Tva-mCherry) |
|
| 1 | Dohaku et al., 2019 |
1 - 8 of 8
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEYP-118E10 | ZFIN Curated Data | |
Encodes | EST | fj56h04 | ZFIN Curated Data | |
Encodes | cDNA | MGC:112357 | ZFIN Curated Data |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001029952 (1) | 1826 nt | ||
Genomic | RefSeq:NW_018394942 (1) | 276620 nt | ||
Polypeptide | UniProtKB:A0AB32TA60 (1) | 692 aa |
- Kim, T.Y., Roychaudhury, A., Kim, H.T., Choi, T.I., Baek, S.T., Thyme, S.B., Kim, C.H. (2024) Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536. Translational psychiatry. 14:8282
- Koyama, W., Hosomi, R., Matsuda, K., Kawakami, K., Hibi, M., Shimizu, T. (2021) Involvement of cerebellar neural circuits in active avoidance conditioning in zebrafish. eNeuro. 8(3):
- Sanderson, L.E., Lanko, K., Alsagob, M., Almass, R., Al-Ahmadi, N., Najafi, M., Al-Muhaizea, M.A., Alzaidan, H., AlDhalaan, H., Perenthaler, E., van der Linde, H.C., Nikoncuk, A., Kühn, N.A., Antony, D., Owaidah, T.M., Raskin, S., Vieira, L.G.D.R., Mombach, R., Ahangari, N., Silveira, T.R.D., Ameziane, N., Rolfs, A., Alharbi, A., Sabbagh, R.M., AlAhmadi, K., Alawam, B., Ghebeh, H., AlHargan, A., Albader, A.A., Binhumaid, F.S., Goljan, E., Monies, D., Mustafa, O.M., Aldosary, M., AlBakheet, A., Alyounes, B., Almutairi, F., Al-Odaib, A., Aksoy, D.B., Basak, A.N., Palvadeau, R., Trabzuni, D., Rosenfeld, J.A., Karimiani, E.G., Meyer, B.F., Karakas, B., Al-Mohanna, F., Arold, S.T., Colak, D., Maroofian, R., Houlden, H., Bertoli-Avella, A.M., Schmidts, M., Barakat, T.S., van Ham, T.J., Kaya, N. (2021) Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking. Brain : a journal of neurology. 144(3):769-780
- Chang, W., Pedroni, A., Hohendorf, V., Giacomello, S., Hibi, M., Köster, R.W., Ampatzis, K. (2020) Functionally distinct Purkinje cell types show temporal precision in encoding locomotion. Proceedings of the National Academy of Sciences of the United States of America. 117(29):17330-17337
- Hsieh, J.Y., Ulrich, B.N., Issa, F.A., Lin, M.A., Brown, B., Papazian, D.M. (2020) Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo. eLIFE. 9:
- Zhu, J., Wang, H.T., Chen, Y.R., Yan, L.Y., Han, Y.Y., Liu, L.Y., Cao, Y., Liu, Z.Z., Xu, H.A. (2020) The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neuroscience Bulletin. 36(9):1023-1034
- Dohaku, R., Yamaguchi, M., Yamamoto, N., Shimizu, T., Osakada, F., Hibi, M. (2019) Tracing of Afferent Connections in the Zebrafish Cerebellum Using Recombinant Rabies Virus. Frontiers in neural circuits. 13:30
- Kaur, N., Chugh, H., Tomar, V., Sakharkar, M.K., Dass, S.K., Chandra, R. (2019) Cinnamon attenuates adiposity and affects the expression of metabolic genes in Diet-Induced obesity model of zebrafish. Artificial cells, nanomedicine, and biotechnology. 47:2930-2939
- Knogler, L.D., Kist, A.M., Portugues, R. (2019) Motor context dominates output from Purkinje cell functional regions during reflexive visuomotor behaviours. eLIFE. 8:
- Luo, J., Zhang, X., He, S., Lou, Q., Zhai, G., Shi, C., Yin, Z., Zheng, F. (2019) Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology. 28:101355
1 - 10 of 23
Show