Gene
etsrp
- ID
- ZDB-GENE-050622-14
- Name
- ETS1-related protein
- Symbol
- etsrp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on lymphangiogenesis. Acts upstream of or within several processes, including adrenal gland development; circulatory system development; and hemopoiesis. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; head mesenchyme; hematopoietic system; mesoderm; and pharyngeal arch 3-7.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 111 figures from 60 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns422 | Allele with one deletion | Exon 7 | Unknown | CRISPR | |
| bns426 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| ci32Gt | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| ci33 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| ci48Gt | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| s635 | unknown | Unknown | Unknown | not specified | |
| uq13ks | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| y11 | Allele with one insertion | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q5A3 | InterPro | 355 | ||||
| UniProtKB:Q30JB6 | InterPro | 366 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(etsrp:EGFP) |
|
| 4 | (39) | |
| Tg1(etsrp:EGFP) |
|
| 1 | (5) | |
| Tg1(etsrp-gata2a:EGFP) |
|
| 1 | (2) | |
| Tg1(etsrp:mCherry) |
|
| 1 | (4) | |
| Tg(-2.2etsrp:etsrp-EGFP) |
|
|
| 1 | (3) |
| Tg(-2.2etsrp:Kaede) |
|
| 1 | (3) | |
| Tg(-2.3etsrp:etsrp-EGFP) |
|
|
| 1 | (4) |
| Tg2(etsrp:EGFP) |
|
| 1 | (2) | |
| Tg2(etsrp-gata2a:EGFP) |
|
| 1 | (2) | |
| Tg2(etsrp:mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225P5 | ZFIN Curated Data | |
| Encodes | EST | fc49b07 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:153819 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191940 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037375 (1) | 1478 nt | ||
| Genomic | GenBank:BX649388 (1) | 177865 nt | ||
| Polypeptide | UniProtKB:Q30JB6 (1) | 366 aa |
No data available
- Gurung, S., Restrepo, N.K., Anand, S.K., Sittaramane, V., Sumanas, S. (2024) Requirement of a novel gene, drish, in the zebrafish retinal ganglion cell and primary motor axon development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):750-770
- Perens, E.A., Yelon, D. (2024) Drivers of Vessel Progenitor Fate Define Intermediate Mesoderm Dimensions by Inhibiting Kidney Progenitor Specification. Developmental Biology. 517:126-139
- Edwards, H.E., Edgington, M.J., Souder, J.P., Gorelick, D.A. (2023) Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos. Development (Cambridge, England). 150(9)
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, H.B., Hui, S.P., Dobreva, G.D., Kikuchi, K., Helker, C.S.M., Stainier, D.Y.R., Mochizuki, N. (2023) Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental Cell. 58(3):224-238.e7
- Tamaoki, J., Maeda, H., Kobayashi, I., Takeuchi, M., Ohashi, K., Gore, A., Bonkhofer, F., Patient, R., Weinstein, B.M., Kobayashi, M. (2023) LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Developmental Biology. 501:92-103
- Yang, Z., Guo, D., Zhao, J., Li, J., Zhang, R., Zhang, Y., Xu, C., Ke, T., Wang, Q.K. (2023) Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(12):2348-2368
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Casey, M.J., Call, A.M., Thorpe, A.V., Jette, C.A., Engel, M.E., Stewart, R.A. (2022) The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis. iScience. 26:105737105737
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